白细胞内HBV DNA与HBV血清标志物的关系

对250例一般人群血清中HBV标志物类型与白细胞内HBVDNA存在的关系进行了对比观察。结果显示：在HBsAg及HBeAg阳性9例中，4例白细胞内HBVDNA阳性，抗－HBe阳性的9例中仅1例白细胞内HBVDNA阳性。在HBsAg消失后产生抗－HBs的96例中有7例白细胞内HBVDNA阳性。血清HBV标志物全阴性而斑点杂交白细胞内HBVDNA阳性的2例，经原位杂交检测亦证实白细胞内有HBV阳性颗粒。提示：在人体HBV多器官感染中，白细胞亦是重要感染部位和潜隐场所。

Relation between HBV DNA in peripheral blood leucocytes and seromarkers

In this study, contrast observation of the relation between the existing patterns of HBV seromarkers and HBV DNA in leucocytes was made in 250 subjects from an ordinary population. The results showed that in 9 subjects with positive HBsAg and HBeAg, four had positive HBV DNA in leucocytes, but in the 9 subjects with positive anti-HBe only one was HBV DNA positive in leucoeytes. There were 7 persons with positive HBV DNA in leucocytes in 96 subjects in whom anti-HBs produced after HBsAg disappeared. The positive rate of HBV DNA in leucocytes was very low in people who were anti-HBc positive only and were 'nomal' individuals with negative serum HBV markers. In the group of 'normal' persons,2specimens were HBV DNA negative in sera, but were positive in leucocytes by spot hybridization. HBV positive particles in leucocytes were also confirmed by in situ hybridization in these two specimens. It is suggested that in the infection process of multiple organs in human boby, the leucocyte may be an important concealing base.