血清脂联素与胱抑素C检测在糖尿病肾病早期诊断中的价值

目的分析血清脂联素及胱抑素C在糖尿病肾病早期诊断中的价值。方法选取糖尿病患者组85例作为观察对象，并根据尿蛋白排泄率分为三组：正常蛋白尿组，微量蛋白尿组及临床蛋白尿组，同时选择健康体检者30例作为正常对照组。采用酶联免疫吸附试验（ELISA）检测血清脂联素水平，免疫比浊法检测血清胱抑素。结果糖尿病组血清脂联素及胱抑素水平明显低于正常对照组（P〈0．05），而随尿蛋白排泄率的增加，血清脂联素及胱抑素水平逐渐增高（P〈0．05），且血清脂联素与胱抑素呈正相关关系（r=0．652，P〈0．05）。结论糖尿病患者血清APN水平的升高预示肾功能的减退，可用于糖尿病肾病的早期诊断。

EARLY DIAGNOSTIC VALUE OF SERUM ADIPONECTIN AND CYSTATIN C FOR DIABETIC NEPHROPATHY

Objective To evaluate the value of adiponectin and cystatin C on early diagnosis for renal impairment in diabetes. Methods A total of 85 diabetic patients were divided into normal albuminuria group, micro- albuminuria group and macro- albuminuria group according to urine albumin excretion rate in 24 hours. 30 health subjects were enrolled as controls. The serum levels of adiponectin and cys- tatin C were detected by ELISA kit. Results The serum levels of adiponectin and cystatin C in diabetic patients were obviously lower than that in the controls（P〈0.05）. For diabetic patients, the serum levels of adiponectin and cystatin C in macro- albuminuria group were significantly higher than in mi- cro- albuminuria group （P 〈 0. 05）. and they were also significantly higher in micro- albuminura group then that in normal albuminura group（P〈0.05）. The serum level of adiponectin in diabetic pa- tients was positively correlated with the serum levels of cystatin C（r = 0. 652,P〈0.05）. Conclusion In diabetic patients, the elevated serum levels of adiponectin indicates the decline of renal function. It can be used for the early diagnosis and estimation of diabetic nephropathy.