Pathology of flat bladder lesions with emphasis on putative precursors |
| |
| Authors: | Liang ChengDarrell D Davidson Sean R WilliamsonGregory T MacLennan Robert E EmersonRodolfo Montironi Antonio Lopez-Beltran |
| |
| Institution: | Liang Cheng MD Departments of Pathology and Laboratory Medicine and Urology, Indiana University School of Medicine, Indianapolis, USA. Conflicts of interest: none declared; Darrell D Davidson MD Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA. Conflicts of interest: none declared; Sean R Williamson MD Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, MI, USA. Conflicts of interest: none declared; Gregory T MacLennan MD Department of Pathology, Case Western Reserve University, Cleveland, OH, USA. Conflicts of interest: none declared; Robert E Emerson MD Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA. Conflicts of interest: none declared; Rodolfo Montironi MD Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region (Ancona), United Hospitals, Ancona, Italy. Conflicts of interest: none declared; Antonio Lopez-Beltran MD Department of Pathology, Cordoba University, Cordoba, Spain. Conflicts of interest: none declared |
| |
| Abstract: | Flat bladder lesions comprise a spectrum of morphologic changes ranging from reactive atypia to carcinoma in situ (CIS). Differentiating these lesions is important because of differences in patient management and clinical outcome. The precise nature of precursor lesions of bladder cancer remains incompletely understood. Urothelial CIS is the most definitely characterized precursor lesion of high grade bladder cancer. Atypia of unknown significance (AUS) is somewhat controversial. For practical purposes, AUS and reactive urothelial changes should be considered a single entity, since neither lesion has established preneoplastic potential. Simple hyperplasia and papillary hyperplasia are recently identified putative preneoplastic lesions. More recent molecular data also support the precursor nature of intestinal metaplasia and keratinizing squamous metaplasia. In this review, we also discuss the utility of molecular ancillary studies in establishing premalignant lesions, diagnosis, and differential diagnosis of flat bladder lesions. |
| |
| Keywords: | atypia of unknown significance bladder flat lesions molecular pathogenesis precursors urothelial carcinoma in situ urothelial dysplasia |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
