| 人重组促红细胞生成素增强耐缺氧作用的实验研究 |
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| 引用本文： | 杨龙,荣曙,许祥裕,谭维国,陶开华,朱有华.人重组促红细胞生成素增强耐缺氧作用的实验研究[J].中国临床保健杂志,2009,12(4):394-396. |
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| 作者姓名： | 杨龙 荣曙 许祥裕 谭维国 陶开华 朱有华 |
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| 作者单位： | 南京军区疾病预防控制中心医学防护所,南京,210002 |
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| 基金项目： | 全军医药卫生科研基金课题 |
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| 摘 要： | 目的观察人重组促红细胞生成素(EPO)对小鼠缺氧耐受力的影响。方法小鼠随机分为EPO组和对照组,经皮下注射不同剂量的EPO和0.9%氯化钠注射溶液,1次/d,连续1周。检测小鼠血红蛋白、红细胞比容改变,测定常压耐氧实验、亚硝酸中毒存活试验以及急性脑缺血性缺氧试验等指标。结果EPO能明显增加小鼠血液内血红蛋白含量和红细胞比容(与对照组相比,P<0.01),缺氧存活时间显著延长(与对照组相比,P<0.01)。结论EPO能明显增强机体的耐缺氧能力。
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| 关 键 词： | 红细胞生成素 重组 缺氧 小鼠 |
Study on enhancing anoxia endurance function of recombinant human erythropoietin in mice |
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| YANG Long,RONG Shu,XU Xiang-yu,TAN Wei-guo,TAO Kai-hua,ZHU You-hua.Study on enhancing anoxia endurance function of recombinant human erythropoietin in mice[J].Chinese JOurnal of Clinical Healthcare,2009,12(4):394-396. |
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| Authors: | YANG Long RONG Shu XU Xiang-yu TAN Wei-guo TAO Kai-hua ZHU You-hua |
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| Institution: | the Center for Disease Control and Prevention of Nanjing Military District;Nanjing 210002;China |
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| Abstract: | Objective To observe the effects of EPO on hypoxia tolerance in mice.Methods The mice were randomly divided into EPO-treated group and control group,the mice were subcutaneous injection administered different doses of EPO or normal saline respectively once a day for 7 days.Then,the levels of hemoglobin and hematocrit were determined.The survival times of acute hypoxia were measured in anoxia with normal air pressure,in poisoning by nitrite and in acute lack of blood in brain.Results The levels of hemoglobin... |
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| Keywords: | Erythropoietin recombinant Anoxia Mice |
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