首页 | 本学科首页   官方微博 | 高级检索  
     

两性霉素B脂质体鞘内注射治疗新型隐球菌性脑膜炎疗效观察
引用本文:成钢卫,李水彬,罗丽敏,俞万香. 两性霉素B脂质体鞘内注射治疗新型隐球菌性脑膜炎疗效观察[J]. 中国医院用药评价与分析, 2008, 8(5): 382-384
作者姓名:成钢卫  李水彬  罗丽敏  俞万香
作者单位:梅州市人民医院,梅州市,514031
摘    要:目的:探讨两性霉素B鞘内注射治疗新型隐球菌性脑膜炎的可行性。方法:将常规静脉注射两性霉素B后、病情仍难以控制的(脑脊液中新型隐球菌性仍难以转阴,颅内高压持续不降)24例新型隐球菌性脑膜炎患者,随机分为两性霉素B鞘内注射组、两性霉素B脂质体鞘内注射组,鞘内注射剂量从0.1 mg开始,逐渐增加剂量,直到出现难以耐受的不良反应或每次注射剂量达到1 mg。结果:患者可以较好地耐受两性霉素B脂质体鞘内注射,鞘内注射两性霉素B脂质体发生不良反应的几率及严重程度明显低于普通两性霉素B。结论:两性霉素B脂质体鞘内注射治疗新型隐球菌性脑膜炎具有可行性。

关 键 词:两性霉素B  两性霉素B脂质体  新型隐球菌性脑膜炎

Feasibility of Treating Cryptococcus Neoformans Meningitis with Intrathecal Lipid Amphotericin B
CHENG Gang-wei,LI Shui-bin,LUO li-min,YU Wan-xiang. Feasibility of Treating Cryptococcus Neoformans Meningitis with Intrathecal Lipid Amphotericin B[J]. Evaluation and Analysis of Drug-Use in Hospital of China, 2008, 8(5): 382-384
Authors:CHENG Gang-wei  LI Shui-bin  LUO li-min  YU Wan-xiang
Affiliation:(Meizhou Municipal People's Hospital, Meizhou 514031, China)
Abstract:OBJECTIVE: To explore the feasibility of intrathecal lipid amphotericin B in the management of cryptococcus neoformans meningitis. METHODS: 24 patients with cryptococcus neoformans meningitis showing no recovery after treatment with routine intravenous administration of amphotericin B (AMB) (i. e. cryptococcus neoformans in cerebrospinal fluid were positive and acute intracranial hypertension was continued) were randomly assigned to receive intrathecal administration of AMB or liposomal amphotericin B with an initial dose of 0.1 mg/d, which increased step by step until intolerable adverse effect occurred or the 1.0 mg/d dose reached. RESULTS: The patients can tolerate intrathecal administration of liposomal amphotericin B well, and the incidence and severity of adverse effects of liposomal amphotericin B were significantly lower as compared with common amphotericin B. CONCLUSION: It is feasible for intrathccal liposomal amphotcricin B to treat cryptococcus neoformans meningitis.
Keywords:Amphotericin B  Liposomal amphotericin B  Cryptococcus neoformans meningitis
本文献已被 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号