Gene Narcotic Attenuation Program attenuates substance use disorder, a clinical subtype of reward deficiency syndrome |
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Authors: | Thomas J H Chen PhD Kenneth Blum PhD Roger L Waite DC Brian Meshkin BSc John Schoolfield MSc B Williams Downs BSc Eric E Braverman MD Vanessa Arcuri BSc Michael Varshavskiy Seth H Blum BA Julie Mengucci RN Carolyn Reuben MS Tomas Palomo MD PhD |
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Institution: | (1) Chang Jung Christian University, Tainan, Taiwan, Republic of China;(2) Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, 27157 Winston-Salem, NC;(3) GenWellness, Inc., San Diego, California;(4) Salugen, Inc., San Diego, California;(5) Department of Academic Informatics Services, University of Texas Health Science Center, San Antonio, Texas;(6) Allied Nutraceutical Research, Lederach, Pennsylvania;(7) Path Medical Research Foundation, New York, New York;(8) Synaptamine, Inc., San Antonio, Texas;(9) Community Addiction Recovery Association, Sacramento Drug Court Provider, Sacramento, California;(10) Hospital Universitario, Madrid, Spain |
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Abstract: | This study evaluated the effects of a putative activator of brain reward circuitry on outcomes in a 1 -y prospective comprehensive
outpatient clinical program. As part of the Gene Narcotic Attenuation Program, Haveos (Synaptamine)™ was administered for
the treatment of substance use disorder. Seventy-six patients (45 males and 31 females; mean age, 33 y standard deviation,
7.0]) who had been given a diagnosis of serious substance use disorder were recruited. After exclusion of 15 patients who
dropped out before the end of the study, self-reported craving decreased from program entrance to 12 wk (visual analog scale
whereby 0 represents no craving and 5, the strongest craving) for 61 compliant patients (mean decrease, 2.85, 95% confidence
interval Cl], 2.65, 3.05); this improvement was significant (P < .001). Building up to relapse scores (each of 5 individual items and summary value) showed similar improvement after 1
y of treatment; the mean decrease in scores was significant for stress (t=3.3; P=.002), depression (t=4.0;P < .001), anger (t=4.4;P < .001), anxiety (t=4.5,P < .001), drug craving (t=5.4,P < .001), and summary building up to relapse (t=4.1;P < .001). Also, recovery score measures of energy level (t=8.4;P < .001) and ability to refrain from drug-seeking behavior (t=7.4;P < .001) showed significant mean increases from entry to 1 y. During the study, the alcoholic dropout rate was only 7% (4
of 57), which was significantly (Fisher’s exact test,P < .001) lower than the 73% (11 of 15) dropout rate reported for psychostimulant users. Although these results are significant,
any interpretation must await the performance of rigorous double-blind studies. |
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Keywords: | substance use disorder catecholamine-O-methyltransferase inhibition enkephalinase inhibition neurotransmitter precursors Haveos (Synaptamine)™ reward deficiency syndrome (RDS) |
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