Some neuropeptides as modulators of experimental contact allergy |
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| Authors: | Joanna,Wallengren Halvor,Mö ller |
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| Affiliation: | Department of Dermatology, Lund University, Malm?, Sweden. |
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| Abstract: | The role of some peptides in allergic contact dermatitis was investigated. The neuropeptides: substance P (SP), vasoactivc intestinal peptide (VIP) and somatostatin as well as the SP antagonist. Spantide, were injected into the same skin sites is the antigen in patients with contact allergy to nickel. The neuropeptides did not influence the eczematous reaction but spantide diminished it. This might speak for a pathogenetic role of SP in allergic, contact dermatitis. |
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| Keywords: | allergic contact dermatitis nickel neuropeptides substance P vasoactive intestinal peptide somatostatin spantide |
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