电针对急性脑梗死家兔血脑屏障的保护作用及其机制

目的 探讨电针(EA)对急性脑梗死家兔血脑屏障(BBB)的保护作用及其可能机理。方法 采用家兔自体血栓栓塞，建立急性脑梗死家兔模型，电针刺激督脉经穴“百会”、“水沟”穴，观察电针对急性脑梗死家兔血浆心钠素(ANP)和脑组织中环腺苷酸(cAMP)、环鸟苷酸(cGMP)含量的影响。结果 与模型组比较，模型电针组血浆中ANP含量和脑组织中cAMP含量明显升高，而脑组织中cGMP含量明显降低，cAMP／cGMP升高且趋于正常。结论 电针对急性脑梗死家兔BBB具有明显的保护和修复作用。其作用机制可能与电针具有升高血浆中ANP含量，升高脑组织中cAMP含量有关，降低脑组织中cGMP含量，从而起到保护和修复BBB的作用。

Electroacupuncture is protective to the blood-brain barrier in rabbit with acute cerebral infarction

Objective To observe whether electroacupuncture (EA) is protective to the blood-brain barrier (BBB) in rabbits with acute cerebral infarction and explore the underlying mechanisms. Methods Eighty rabbits were used in this study. After establishing the acute cerebral infarction rabbit model,all the animals were randomly allocated to a model group and an EA group. The acupoint "Bai Hui" and "Shui Gou" in Du meridian in the rabbits of the experimental group were stimulated by EA. The content of ANP,cAMP and cGMP was examined. Results Compared with the model group,the content of ANP in blood plasma and cAMP in brain tissue of the EA group significantly increased,while the content of cGMP decreased,the ratio cAMP/cGMP increased nearly to the normal level. Conclusion The EA exerted protective effect and promoted repair of BBB in rabbits with acute cerebral infarction,which might be modulated by the changes of the content of ANP in blood plasma and cAMP,cGMP in brain tissue.