| 无创性肢体缺血后适应对大鼠心梗后再灌注时心肌的保护作用 |
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| 引用本文： | 洪小剑,寇俊杰,王旭红,武英彪,梁克纪,傅世英,李为民. 无创性肢体缺血后适应对大鼠心梗后再灌注时心肌的保护作用[J]. 黑龙江医学, 2011, 35(4): 252-254,258. DOI: 10.3969/j.issn.1004-5775.2011.04.005 |
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| 作者姓名： | 洪小剑 寇俊杰 王旭红 武英彪 梁克纪 傅世英 李为民 |
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| 作者单位： | 哈尔滨医科大学附属第一医院心内六科,黑龙江,哈尔滨,150001 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目，黑龙江省自然科学基金项目 |
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| 摘 要： | 目的 探讨无创性肢体缺血后适应(RPOC)是否具有减轻大鼠心梗后再灌注时心肌损伤的作用.方法 所有大鼠随机分为3组(每组15只):心肌缺血/再灌注损伤组(L/R)、再灌注前冠脉缺血后适应组(CPOC)和再灌注同时无创性肢体缺血后适应组(RPOC).观察再灌注期间心电、心肌缺血范围(AAR)、心肌梗死范围(IA)、梗死范...
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| 关 键 词： | 心肌梗死 缺血/再灌注损伤 缺血预适应 缺血后适应 远程缺血后适应 |
Protection of Noninvasive Limb Ischemic Postconditioning During Reperfusion in Myocardial Infarction Rats |
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| Affiliation: | HONG Xiao-jian,KOU Jun-jie,WANG Xu-hong,et al.(Department of Cardiology,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,CHINA) |
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| Abstract: | Objective To observe the protective effects of noninvasive limb ischemic postconditioning during reperfusion in acute myocardial infarction rats.Methods All wistar rats were randomly divided into three groups(n=15 in each group):(1)Myocardial ischemia/reperfusion(I/R);(2) Coronary artery ischemic postconditionng(CPOC);(3) Remote postconditioning(RPOC).We recorded the incidence rate of ventricular arrhythmogenesis(VA) during reperfusion,and measured myocardial area at risk(AAR)、myocardial infarcted area(IA)、IA/AAR、MB isoenzyme of creatine kinase(CK-MB) after 3 h of reperfusion.Results VA、IA、IA/AAR、CK-MB were significantly less in RPOC and CPOC as compared to I/R(P<0.01).Conclusion The noninvasive limb ischemic postconditioning during reperfusion could reduce the incidence rate of arrhythmogenesis and prevent myocardial ischemia-reperfusion injury. |
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| Keywords: | Myocardial infarction Ischemia/reperfusion injury Ischemic preconditioning Ischemic postconditioning Remote postconditioning |
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