|
|||||
|
|
Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway |
|
| Authors: | Milton W Datta Ana Maria Hernandez Michael J Schlicht Andrea J Kahler Amy M DeGueme Rajiv Dhir Rajal B Shah Cindy Farach-Carson Andrea Barrett Sumana Datta |
| Affiliation: | (1) Departments of Pathology and Urology, Emory University, Atlanta, GA 30322, USA;(2) Department of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU College Station, Texas 77843-2128, USA;(3) Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15232, USA;(4) Department of Pathology, University of Michigan, 1500 Catherine Ave, Ann Arbor, MI 48109, USA;(5) Department of Biological Sciences, University of Delaware, 304 Wolfe Hall, Newark, DE 19716, USA |
| Abstract: | BackgroundGenetic studies associated the CAPB locus with familial risk of brain and prostate cancers. We have identified HSPG2 (Perlecan) as a candidate gene for CAPB. Previously we have linked Perlecan to Hedgehog signaling in Drosophila. More recently, we have demonstrated the importance of Hedgehog signaling in humans for advanced prostate cancer. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |