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Haplotype analysis suggest common founders in carriers of the recurrent BRCA2 mutation, 3398delAAAAG, in French Canadian hereditary breast and/ovarian cancer families |
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| Authors: | Kathleen K Oros Guy Leblanc Suzanna L Arcand Zhen Shen Chantal Perret Anne-Marie Mes-Masson William D Foulkes Parviz Ghadirian Diane Provencher Patricia N Tonin |
| Institution: | 1. Department of Human Genetics, McGill University, Montreal, Canada 2. Program of Surgical oncology, Department of Oncology, McGill University, Montreal, Canada 3. Research Institute of the McGill University Health Centre, Montreal, Canada 4. Centre de recherche du Centre Hospitalier de l'Université de Montréal/Institut du cancer de Montréal, H?pital Notre-Dame, Montréal, Canada 5. Département de médicine, Université de Montréal, Montreal, Canada 6. Program in Cancer Genetics, Departments of Oncology and Medicine, McGill University, Montreal, Canada 7. Unité de recherché en épidémiologie, Centre Hospitalier de l'Université de Montréal, H?pital H?tel-Dieu, Faculté de médicine, Université de Montréal, Montréal, Canada 8. Division de gynécologie oncologique, Université de Montréal, Montreal, Canada |
| Abstract: | BackgroundThe 3398delAAAAG mutation in BRCA2 was recently found to recur in breast and/or ovarian cancer families from the French Canadian population of Quebec, a population that has genetic attributes consistent with a founder effect. To characterize the contribution of this mutation in this population, this study established the frequency of this mutation in breast and ovarian cancer cases unselected for family history of cancer, and determined if mutation carriers shared a common ancestry. |
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