代谢综合征患者的高敏C反应蛋白及靶器官损害

目的探讨高敏C反应蛋白(hs-CRP)与代谢综合征组分及其靶器官损害的关系。方法389例老年高血压、糖尿病或代谢综合征患者用乳胶免疫增强比浊法检测血清hs-CRP,分析hs-CRP与血脂、血糖、血压、腹围的关系;同时测定了289例患者颈动脉内-中膜厚度(IMT)、267例左室质量指数(LVMI)和343例尿蛋白排泄率(UAER)作为判断是否存在代谢综合征靶器官损害的指标,分析hs-CRP与IMT、LVMI和UAER的关系。结果血清hs-CRP水平随着代谢综合征组分成分数量的增加而升高,当其组成成分≥3个时,hs-CRP水平明显升高。相关分析表明hs-CRP浓度与甘油三酯、腹围、收缩压、舒张压、空腹血糖呈正相关,与高密度脂蛋白胆固醇呈负相关;血清hs-CRP水平与IMT、LVMI和UAER呈正相关关系,当hs-CRP水平升高时,可增加代谢综合征靶器官损害的程度和范围。结论血清hs-CRP水平不仅与代谢综合征组成成分相关,而且与其靶器官损害程度密切联系。

High-sensitivity C reactive protein in patients with metabolic syndrome and target organ damages

Objective To determine the association of the serum levels of high-sensitivity C reactive protein(hs-CRP)and components and target organ damage in patients with the metabolic syndrome(MS).Methodes Total 389 participants were included in this study.MS criteria was defined by modified NCEP-ATPⅢ.Serum hs-CRP,fasting lipids and blood glucose(FPG),blood pressure,and waist circumference,left ventricular mass index(LVMI),intima-media thickness(IMT)and urinary albumin excretion rate(UAER)were measured in all the participants.Results Increasing numbers of the MS components resulted in higher serum levels of hs-CRP,especially,baseline level of hs-CRP for those 3 or more MS components was much higher than that for those with 2 or less MS components.Hs-CRP level was highly significant positive correlated with TG,waist circumference,SBP,DBP,FPG,and a significant negative correlation between hs-CRP and HDL-C.Apart from this,there was a statistically significantly positive correlation between hs-CRP and IMT,LVMI and UAER(P<0.01).Conclusion The results indicated that serum hs-CRP level was closely related to the components and its target organ damage in patients with MS.