| DNA-PKcs在鼻咽癌组织中的表达及临床相关性研究 |
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| 引用本文： | 侯宇,李文辉,杨胜刚,秦继勇,夏群. DNA-PKcs在鼻咽癌组织中的表达及临床相关性研究[J]. 现代肿瘤医学, 2008, 16(11) |
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| 作者姓名： | 侯宇 李文辉 杨胜刚 秦继勇 夏群 |
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| 作者单位： | 昆明医学院第三附属医院,云南省肿瘤医院,放疗科,云南,昆明,650118 |
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| 基金项目： | 云南省教育厅资助项目 |
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| 摘 要： | 目的:研究DNA-PKcs蛋白的表达与鼻咽癌各临床指标的相关性,探寻DNA-PKcs的表达与鼻咽癌放射敏感性的关系。方法:应用免疫组化法测定65例鼻咽低分化鳞癌DNA-PKcs蛋白的表达。结果:DNA-PKcs的表达在原发灶退缩情况、性别、患病年龄、原发灶大小、淋巴结转移等观察指标中其差异未见有统计学意义;II期 III期病例,与IVa期病例相比较,DNA-PKcs表达的差异有统计学意义(P=0.027);癌组织与癌旁正常组织DNA-PKcs的表达差异未见有统计学意义。结论:鼻咽癌组织中DNA-PKcs蛋白的表达与放疗后原发灶退缩情况无关,提示与鼻咽癌放射敏感性无确切相关性;该蛋白的表达与临床分期有一定关系;鼻咽癌癌组织与癌旁正常组织DNA-PKcs蛋白的表达具有一致性。
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| 关 键 词： | 鼻咽癌 放射治疗 DNA依赖蛋白激酶（DNA-PK） 免疫组化 放射敏感性 |
Expression of DNA-PKcs in nasopharyngeal carcinoma tissue and its clinical signiflcance |
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| HOU Yu,LI Wen-hui,YANG Sheng-gang,QIN Ji-yong,XIA Qun. Expression of DNA-PKcs in nasopharyngeal carcinoma tissue and its clinical signiflcance[J]. Journal of Modern Oncology, 2008, 16(11) |
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| Authors: | HOU Yu LI Wen-hui YANG Sheng-gang QIN Ji-yong XIA Qun |
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| Abstract: | Objective:To study the DNA-PKcs protein expression and its clinical significance in nasopharyngeal carcinoma.Methods: The expression of DNA-PKcs was determined by immunohistochemical technique.Results: There were no differences of DNA-PKcs protein expression for observed clinical index,except for stage IVa and stage II III(P=0.027).The protein expression was no difference between carcinoma tissue and normal tissue.Conclusion: The expression of DNA-PKcs has no relationship with radiosensitivity in NPC;There was difference in DNA-PKcs protein expression between clinlcal stage IVa and II III;No obvious difference can be observed in the expression of DNA-PKcs between carcinoma tissue and normal tissue. |
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| Keywords: | nasopharyngeal carcinoma radiotherapy DNA-PK immunohistochemistry radiosensitivity |
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