| 免疫检查点抑制剂致结肠炎的研究进展 |
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| 引用本文： | 汪龙,王莉,周宁宁,钟春生,汪娟,张莉. 免疫检查点抑制剂致结肠炎的研究进展[J]. 中国新药与临床杂志, 2019, 0(3): 135-140 |
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| 作者姓名： | 汪龙 王莉 周宁宁 钟春生 汪娟 张莉 |
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| 作者单位： | 1.蚌埠市第三人民医院药学部;2.蚌埠市第三人民医院肿瘤内科;3.上海市杨浦区市东医院急诊科;4.蚌埠医学院第二附属医院药学部 |
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| 摘 要： | 免疫检查点抑制剂(ICPi)靶向作用于细胞毒性T淋巴细胞相关抗原4 (CTLA-4)和程序性死亡受体/配体1 (PD-1/PD-L1),通过增强T细胞活性而发挥抗肿瘤作用,但这也会引起机体正常免疫耐受缺失,导致免疫相关的不良反应(irAEs)发生。结肠炎为其常见的irAEs之一,其发生的危险因素涉及ICPi药物种类、使用剂量,联用非甾体抗炎药,患者基线微生物群状况和肿瘤类型等。ICPi致结肠炎的典型症状为腹泻,严重时可能诱发重度脱水和肠穿孔,应视患者的具体情况给予抗腹泻药物、补液、糖皮质激素或英夫利昔单抗治疗。
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| 关 键 词： | 免疫检查点抑制剂 结肠炎 腹泻 药物相关性副作用和不良反应 |
Research progress of immune checkpoint inhibitors-induced colitis |
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| WANG Long,WANG Li,ZHOU Ning-ning,ZHONG Clnm-sheng,WANG Juan,ZHANG Li. Research progress of immune checkpoint inhibitors-induced colitis[J]. Chinese Journal of New Drugs and Clinical Remedies, 2019, 0(3): 135-140 |
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| Authors: | WANG Long WANG Li ZHOU Ning-ning ZHONG Clnm-sheng WANG Juan ZHANG Li |
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| Affiliation: | (Department of Pharmacy,the Third People's Hospital of Bengbu,Bengbu ANHUI 233099,China;Medical Oncology,the Third People's Hospital of Bengbu,Bengbu ANHUI 233099,China;Department of Emergency, East City Hospital of Shanghai Yangpu District, SHANGHAI 200438, China;Department of Pharmacy,the Second Affilialed Hospital of Bengbu Medical College,Bengbu ANHUI 233040,China) |
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| Abstract: | WANG Long;WANG Li;ZHOU Ning-ning;ZHONG Clnm-sheng;WANG Juan;ZHANG Li(Department of Pharmacy,the Third People's Hospital of Bengbu,Bengbu ANHUI 233099,China;Medical Oncology,the Third People's Hospital of Bengbu,Bengbu ANHUI 233099,China;Department of Emergency, East City Hospital of Shanghai Yangpu District, SHANGHAI 200438, China;Department of Pharmacy,the Second Affilialed Hospital of Bengbu Medical College,Bengbu ANHUI 233040,China) |
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| Keywords: | immune checkpoint inhibitors colitis diarrhea drug - related side effects and adverse reactions |
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