The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis |
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| Authors: | Cardone Rosa A Casavola Valeria Reshkin Stephan J |
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| Affiliation: | Department of General and Environmental Physiology, University of Bari, Via Amendola 165/A, 70126 Bari, Italy. |
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| Abstract: | Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microenvironment in malignant invasion. This microenvironment is acidified primarily by the tumour-cell Na(+)/H(+) exchanger NHE1 and the H(+)/lactate cotransporter, which are activated in cancer cells. NHE1 also regulates formation of invadopodia - cell structures that mediate tumour cell migration and invasion. How do these alterations of the metabolic microenvironment and cell invasiveness contribute to tumour formation and progression? |
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