| 白桦提取物对大鼠下丘脑组织中5-HT含量的影响* |
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| 引用本文： | 杜旭,刘璐,薛欣. 白桦提取物对大鼠下丘脑组织中5-HT含量的影响*[J]. 黑龙江医药, 2001, 14(2): 103-104 |
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| 作者姓名： | 杜旭 刘璐 薛欣 |
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| 作者单位： | 哈尔滨医科大学第一临床医学院 |
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| 基金项目： | 东北白桦叶解热作用研究 黑龙江省自然科学基金,类别 D,编号9523 |
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| 摘 要： | 目的：研究白桦提取物对酵母致大鼠发热的影响及对下丘脑组织中5－HT含量的影响。为其解热降温机理作用提供依据。方法：用荧光分光光度计在480nm/365nm处测定5－HT含量。单位以每mg鲜脑组织含5－HT的ng数表示。结果：酵母模型组大鼠体温及正丘脑组织中5－HT含量均明显高于正常对照组，给药组大鼠给予白桦提取物后1h体温显著下降，正丘脑组织中5－HT含量亦明显降低。讨论：本实验结果显示：白桦提取物对酵母致发热大鼠有明显的解热作用，其解热作用与影响体温调节中枢介质5－HT的含量有关。
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| 关 键 词： | 白桦提取物 解热作用 5－羟色胺 5－HT 大鼠 下丘脑 |
| 修稿时间： | 2000-12-16 |
Effect Betula HaatyphyHa suk(BPS) Extract on 5- HT Hypothalamus of Rats |
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| Du Xu Medicament Department,First Clinical College of Harbin Medical University. Effect Betula HaatyphyHa suk(BPS) Extract on 5- HT Hypothalamus of Rats[J]. Heilongjiang Medicine, 2001, 14(2): 103-104 |
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| Authors: | Du Xu Medicament Department First Clinical College of Harbin Medical University |
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| Abstract: | Objective:That study effect of BPS extract on in febrile rats induced by zymonsa and on 5- HT in hypothalamus of rats,provide a scientific evidence for the antipyretic and follwing effects mechanism. Method:A method with fluorospectrophotometry was established for the detemination of 5 - HT.The excitation wavelength was 365nm,the emission wavelength was 480nm.Result:The temperature and content 5 -HT in Hypothalamus of rats in model group are all higher than those in control group.The temperature of rats in drug -given group fall remarkably after being given drug lhour 5-HT in Hypothalamus fall remarkably also. Conclusion:BPS extract have antipyretic effect in febrile rats induced by aymosa and its antipyretic effect was associated with its reducing the contents of 5 -HT in hypothalamus. |
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| Keywords: | Betula Plaatyphylla suk Antipyretic effect 5-hydroxytryptamine(5-TH) |
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