| 卡马西平对大鼠海马星形胶质细胞形态和GFAP表达的影响 |
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| 引用本文： | 李杏色,柴锡庆.卡马西平对大鼠海马星形胶质细胞形态和GFAP表达的影响[J].基础医学与临床,2006,26(10):1104-1107. |
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| 作者姓名： | 李杏色 柴锡庆 |
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| 作者单位： | 河北医科大学,研究生院,河北,石家庄,050017;河北医药化工职业技术学院,河北,石家庄,050031 |
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| 摘 要： | 目的观察治疗剂量卡马西平对SD大鼠海马星形胶质细胞形态和胶质纤维酸性蛋白(GFAP)表达的影响。方法治疗剂量卡马西平每24 h单次灌胃给药后,于不同时间点经心脏灌注,取脑;GFAP免疫组化染色测量海马GFAP阳性细胞数量及形态。结果1周组海马CA1区星形胶质细胞的形态及GFAP表达无变化,1个月组星形胶质细胞数量及GFAP表达量无明显增加,3个月组GFAP阳性细胞数显著增加,达对照组的1.74倍(P<0.05);并伴细胞体积增大,侧支增多。结论治疗剂量的卡马西平对星形胶质细胞形态和GFAP表达的影响呈时间依赖性。
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| 关 键 词： | 卡马西平 海马 星形胶质细胞 GFAP |
| 文章编号： | 1001-6325(2006)10-1104-04 |
| 收稿时间： | 2005-11-22 |
| 修稿时间： | 2006-04-20 |
Effects of carbamazepine on the morphology of astrocytes and GFAP expression in hippocampus of rats |
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| LI Xing-se,CHAI Xi-qing.Effects of carbamazepine on the morphology of astrocytes and GFAP expression in hippocampus of rats[J].Basic Medical Sciences and Clinics,2006,26(10):1104-1107. |
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| Authors: | LI Xing-se CHAI Xi-qing |
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| Institution: | Graduate College of Hebei Medical University, Shijiazhuang 050017, China |
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| Abstract: | Obiective To observe the effects of carbamazepine on morphology and glial fibrillary acidic protein(GFAP)expression of astrocytes in hippocampus of Sprague-Dawley rats.Methods Astrocytic expression was observed with GFAP immunohistochemical staining.Results Compared to control group,GFAP immunoreactivity and the number of GFAP-positive astrocytes were significantly increased after 3 months of carbamazepine administration.Conclusion The changes of astrocytic expression induced by carbamazepine are time-dependent. |
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| Keywords: | carbamazepine hippocampus astrocyte GFAP |
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