| 乙型肝炎病毒感染者血清前S1抗原检测的临床意义 |
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| 引用本文： | 朱海龙,刘志辉,梁淑慧.乙型肝炎病毒感染者血清前S1抗原检测的临床意义[J].现代医药卫生,2006,22(21):3243-3244. |
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| 作者姓名： | 朱海龙 刘志辉 梁淑慧 |
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| 作者单位： | 广州中医药大学第一附属医院检验科,广东,广州,510405 |
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| 摘 要： | 目的：分析乙型肝炎病毒（HBV）前S1抗原与其他HBV标志物的关系，并探讨其相应的临床意义。方法：用酶联免疫吸附试验方法（EHSA）检测95例HBV病毒感染者血清标志物和前S1抗原，并对结果进行分析。结果：前S1抗原在HBeAg阳性组合中的检出率明显高于HBeAg阴性组合者（P〈0．05）；HBV感染者抗HBc-IgM与前S1抗原检出率差异有显著性（P〈0．05），HbcAb-IgM与前S1抗原的关系不密切（r=-0．1045）。结论：前S1抗原是反映HBV感染、复制的指标，与HBV标志物联合检测可为乙型肝炎的诊断、治疗提供更可靠的依据。
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| 关 键 词： | 乙肝病毒标志物 乙肝病毒前S1抗原 酶联免疫吸附试验（ELISA） |
| 文章编号： | 1009-5519（2006）21-3243-02 |
| 收稿时间： | 2006-05-30 |
| 修稿时间： | 2006年5月30日 |
The clinical significance of detecting Pre-S1 antigen in patients with hepatitis B |
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| ZHU Hai-long,LIU Zhi-hui,LIANG Shu-hui.The clinical significance of detecting Pre-S1 antigen in patients with hepatitis B[J].Modern Medicine Health,2006,22(21):3243-3244. |
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| Authors: | ZHU Hai-long LIU Zhi-hui LIANG Shu-hui |
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| Abstract: | Objective:To investigate the correlation studies on hepatitis B virus pre-S1 protein and standard HBV markers in patients with hepatitis B and explore its clinic values.Methods:Samples collected from 95 hepatitis B patients were analyzed in the study. The HBV Pre-S1 antigen and standard HBV markers (HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc) were analyzed by ELISA. Results:The positive rate of Pre-S1 antigen in the HBeAg(+) group was higher than that in the HBeAg(-) group (P<0.05). It was found that positive rates of Pre S1 and anti-HBc-IgM were significant difference (P<0.05), It was found that Pre S1 were correlated with Anti-HBc-IgM with the coefficient being -0.1045.Conclusion:Pre-S1antigen is a satisfactory mark to reflex Hepatitis B Virus is existing or replication, and it can be regarded as a supplementary for hepatitis B markers to early diagnosis of hepatitis B virus infection. |
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| Keywords: | Hepatitis B virus markers Hepatitis B virus Pre S1 antigen ELISA |
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