盐酸羟考酮联合丙泊酚应用于无痛纤支镜对血流动力学及相关指标的影响

目的 探讨盐酸羟考酮联合丙泊酚应用于无痛纤维支气管镜(以下简称纤支镜)对血流动力学及相关指标的影响.方法 选取自2016年1月至2017年5月接收纤支镜检查的患者90例,采用随机数字表法将90例患者均分为舒芬太尼十丙泊酚组(A组)和盐酸羟考酮十丙泊酚组(B组),每组45例.观察两组患者血流动力学指标、术中丙泊酚用量及不良反应发生率.结果 开始检查纤支镜抵达声门时(T2)时A组呼吸频率(RR)指标明显高于B组(P＜0.05);纤支镜经过气管隆嵴时(T3)、检查完成时(T4)A组患者平均动脉压(MAP)、心律(HR)、血氧饱和度(SpO2)、RR指标均明显高于B组(P＜0.05);检查完成后10 min(T5)时A组患者RR指标明显高于B组,差异有统计学意义(P＜0.05);丙泊酚的用量A组明显高于B组(P＜0.05);A组患者检查后不良反应发生率为31.11％,明显高于B组的6.67％,两组比较差异有统计学意义(P＜0.05).结论 盐酸羟考酮联合丙泊酚比舒芬太尼联合丙泊酚更能稳定在纤支镜检查过程中血流动力学参数的改变,且可减少丙泊酚用量和不良反应发生率.

Effects of oxycodone hydrochloride combined with propofol on hemodynamics and related indexes in painless fiberoptic bronchoscopy

Objective To investigate the effects of oxycodone hydrochloride combined with propofol on hemodynamics and related indicators in painless fiberoptic bronchoscopy.Methods Ninety patients receiving fiberoptic bronchoscopic examination from January 2016 to May 2017 were selected and divided into the sufentanil+propofol group(group A) and oxycodone hydrochloride+propofol group(group B) according to the random number table method 45 cases in each group.The hemodynamic indicators,intraoperative propofol dosage and incidence rate of adverse reactions in both groups were observed.Results The respiratory rate(RR) in the bronchoscope reaching the glottis(T2) in the group A was significantly higher than that in the group B (P＜ 0.05);mean arterial pressure(MAP),heart rate(HR),blood oxygen saturation(SpO2) and RR at the bronchoscope passing trachea carina(T3) and examination completing(T4) in the group A were significantly higher than those in the group B(P＜0.05).RR at 10 min after the examination completing(T5) in the group A was significantly higher than that in the group B,the difference was statistically significant(P＜0.05).The propofol dosage in the group A was significantlyhigher than that in the group B(P＜0.05);the incidence rate of adverse reactions in the group A was 31.11％,which was significantly higher than 6.67％ in the group B,the difference was statistically significant(P＜0.05).Conclusion Oxycodone hydrochloride combined with propofol can more stabilizes the change of hemodynamic parameters during the bronchofibroscopic examination process compared with sufentanil combined with propofol and can reduce the propofol dosage and incidence rate of adverse reactions.