纳洛酮在ICU中的应用

作者在ICU中应用钢治团治疗中毒性休克、败血症、细菌性脑膜炎、一氧化碳中毒、脑梗死共104例，除细菌性脑膜炎病例数过少未作比较外，与对照组相比各指标均有显著性差异（P＜0．05）。结果认为，1．纳洛酮在治疗严重感染性疾息时，通过结抗体内β-内啡肽，稳定细胞微粒体膜阻止其酶的释放而发挥抗炎作用；2．纳洛酮具有催醒和促进神经系统病变恢复的作用；3．纳洛酮具有高效抗休克作用，特别是感染性休克。

Clinical Use of Naloxone in ICU

A total number of lo4 cases of septic shock, septecemia, bacterial meningitis , carbon monoxide poisoning or cerebral infarction were treated by naloxone in ICU.Except for bacterial meningitis (cases not enough) all parameters showed significant differences in compare with those of the conthlled: The results showed that (1)In the treatment of septic shock, the antiinflammatory action of naloxone is caused by antagonising a enkephaline stabilizing membrane of microsome and blocking the release of the enzyme; (2)naloxone is a potent awakening drug and can be used to promote the recovery of the nervous system; (3)naloxone is highly effective in antishock action especially in septic shock.