联合99mTc-MIBI与99mTcO-4显像鉴别甲状腺结节的临床价值 |
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引用本文: | 叶智卫,;刘菁华,;高克加,;周瑞明. 联合99mTc-MIBI与99mTcO-4显像鉴别甲状腺结节的临床价值[J]. 上海医学影像, 2014, 0(3): 212-215 |
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作者姓名: | 叶智卫, 刘菁华, 高克加, 周瑞明 |
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作者单位: | [1]上海市黄浦区中心医院核医学科,上海200002; [2]上海市儿童医院核医学科,上海200040 |
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基金项目: | 黄浦区卫生局科研课题[No:(2009)HGG-22];上海核医学会临床核医学专业委员会资金资助(2009年上海市核医学青年骨干提升计划,No:2009-NM-06) |
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摘 要: | 目的:探讨核医学99mTcO-4与99mTc-MIBI联合显像鉴别甲状腺结节良恶性的临床价值。方法对入选的40例甲状腺结节病例术前行甲状腺99mTcO-4显像、99mTc-MIBI显像,根据结节的99mTc-MIBI与99mTcO-4摄取值,计算99mTc-MIBI /99mTcO-4摄取比值(即M/T值)。根据术后病理,分析M/T值及血清人促甲状腺激素(hTSH)水平与结节良恶性的关系。结果40例中,5例甲状腺结节M/T比值≥2.0,病理结果为恶性结节(乳头状癌、滤泡状癌),与M/T值存在相关性(P〈0.05);其余35例为良性结节(腺瘤、囊腺瘤),M/T值均〈2.0。联合甲状腺99mTcO-4和99mTc-MIBI显像诊断甲状腺恶性结节的灵敏度为100%,特异度为94.3%,准确率为95%。良性结节与hTSH水平增高有关(P〈0.05)。结论联合甲状腺99mTcO-4和99mTc-MIBI显像可对甲状腺结节的良恶性进行鉴别诊断,具有临床应用价值。
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关 键 词: | 99mTcO-4 99mTc-MIBI 显像 甲状腺结节 |
Clinical value of 99mTc-MIBI scintigraphy combined with 99mTcO-4 scintigraphy in differential diagnosis of benign and malignant thyroid nodules |
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Affiliation: | YE Zhi-wei, LIU Jing-hua, GAO Ke-jia, ZHOU Rui-ming (1.Department of Nuclear Medicine, Huangpu Central Hospital, Shanghai 200002, China; 2.Department of Nuclear Medicine, Shanghai Children's Hospital, Shanghai 200040, China) |
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Abstract: | Objective To investigate the clinical value of 99mTc-MIBI scintigraphy combined with 99mTcO-4 scintigraphy in differential diagnosis of benign and malignant thyroid nodules. Methods Forty cases with thyroid nodules were performed 99mTcO-4 scintigraphy and 99mTc-MIBI scintigraphy before surgery. The region of interest (ROI) uptake ratio of 99mTc-MIBI to 99mTcO4ˉ (M/T value) was calculated. The relationship between M/T value or blood human thyroid stimulating hormone (hTSH) level and benign and malignant nodules were analyzed according to the postoperative pathology. Results Among 40 cases, there were 5 cases with M/T value ≥2.0 and pathological results confirmed malignant (papillary carcinoma and follicular carcinoma). The pathological result was correlated with M/T value (P〈0.05). The rest 35 cases with M/T values 〈2.0 were diagnosed benign nodules (adenoma and cystadenoma). The sensitivity was 100%, specificity was 94.3%, and accuracy was 95%. The benign nodule was associated with elevated hTSH level (P〈0.05). Conclusion 99mTc-MIBI scintigraphy combined with 99mTcO-4 scintigraphy can differentially diagnose benign thyroid nodules from malignant ones, with application value in clinic. |
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Keywords: | 99mTc-MIBI 99mTc-MIBI Scintigraphy Thyroid nodule |
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