| 豚鼠内耳微循环障碍对血迷路屏障通透性的影响 |
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| 摘 要： |
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| 关 键 词： | 迷路 耳蜗 微循环 毛细血管通透性 内耳局部缺血 |
Effects of microcirculatory disorders of inner ear on blood-labyrinth barrier permeability in guinea pigs] |
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| X Zhang,J Wang. Effects of microcirculatory disorders of inner ear on blood-labyrinth barrier permeability in guinea pigs][J]. Chinese Journal of Otorhinolaryngology, 2000, 35(5): 339-341 |
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| Authors: | X Zhang J Wang |
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| Affiliation: | Department of Otorhinolaryngology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. yingsc@public.cta.cq.cn |
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| Abstract: | OBJECTIVE: To study the changes of blood-labyrinth barrier permeability during cochlea microcirculatory disorders in guinea pigs. METHODS: Using modified method of Evan's blue fluorescence, the changes of permeability of blood-labyrinth barrier were observed in the animal model of cochlea microcirculatory disorders which was induced by photochemical reaction. RESULTS: Amount of Evan's blue passing through the blood-labyrinth barrier was (1.709 +/- 0.769) microgram per guinea pig after 2 hours and (2.849 +/- 0.653) microgram per guinea pig after 4 hours when the cochlea was in microcirculatory disorder. CONCLUSION: The results indicated that the permeability of blood-labyrinth barrier increased when cochlea microcirculatory disorders occurred and the increase of blood-labyrinth barrier permeability may be one of the important mechanisms which causes the cochlear ischemic lesions. |
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