Differential sensitivity of selected rat brain areas to excitatory neurotransmitters released by K+ depolarization |
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Authors: | A Luini O Goldberg V I Teichberg |
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Affiliation: | 1. Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100 Israel;2. Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100 Israel |
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Abstract: | When injected intrathecally in mice in a volume of 5 microliter, adenosine had no effect on tail-flick or hot-plate reaction latencies at dosages up to 1 mM concentration. There were no other behavioral effects observed either. Injecting 1 mM of the adenosine receptor agonist, 5'-N-ethylcarboxamide adenosine (NECA) caused both motor paralysis of the hind-legs with a duration of approximately 4 h and simultaneous antinociception. A slight weakness of the hindlegs, but a profound antinociceptive effect, was observed after the 100 microM dose only. After 10 microM, there was no effect on motor behavior but still a prolongation of the tail-flick and hot-plate reaction latencies. Pretreatment with the adenosine receptor antagonist theophylline attenuated the antinociceptive effect of NECA. Activation of spinal adenosine receptors thus appears to selectively elicit analgesia. |
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Keywords: | subsynaptic receptors excitatory amino acids distribution brain rat |
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