| 重组人骨形成蛋白-2、胶原、珊瑚复合人工骨异位诱导成骨的实验研究 |
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| 引用本文： | 尉文华,毛天球,陈富林,王贺忠,张忠友.重组人骨形成蛋白-2、胶原、珊瑚复合人工骨异位诱导成骨的实验研究[J].现代口腔医学杂志,2000,14(4):231-232. |
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| 作者姓名： | 尉文华 毛天球 陈富林 王贺忠 张忠友 |
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| 作者单位： | 1. 075000,张家口市二五一医院口腔科
2. 第四军医大学口腔医学院颌面外科 |
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| 摘 要： | 目的 采用珊瑚作为载体，胶原作为缓释系统，制血出重组人骨形成蛋白－２（ｒｈＢＭＰ－２）胶原／珊瑚复合人工骨，并评价其骨诱导活性。方法 ｒｈＢＭＰ－２、胶原和珊瑚以一定的方式复合后，植入小鼠股部肌袋内，以单纯珊瑚植入用对照，术后不同取材，通过组织学方法检测骨诱导活性。结果 复合人工骨植入１周诱导软骨形成，２周形成编织骨，４周形成含骨髓的板层骨，同时珊瑚被降解吸收。结果 胶原、珊瑚是ｒｈＢＭＰ－２较理
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| 关 键 词： | rhBMP－2 胶原 珊瑚 复合人工骨 骨诱导 |
| 修稿时间： | 1999-08-03 |
Experimental study on the bone inductivity of rhBMP2 collagen and coral complex |
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| WEI Wenhua,MAO Taoqiu,CHEN Fulin,et al..Experimental study on the bone inductivity of rhBMP2 collagen and coral complex[J].Journal of Modern Stomatology,2000,14(4):231-232. |
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| Authors: | WEI Wenhua MAO Taoqiu CHEN Fulin |
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| Institution: | WEI Wenhua,MAO Taoqiu,CHEN Fulin,et al. No.251 Hospital of PLA,Zhangjiakou 075000 |
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| Abstract: | Objective To observe the bone inductive activity of rhBMP-2/collagen/coral complex.Methods rhBMP-2/collagen/coral complex was implanted into mouse muscle pouch.The samples were observed by histological examination at 1.2.4.weeks post operation.Results 1 week after implantation,neo-cartilage could be seen around the coral , 2 weeks after implantation,woven bone formed and lamellar bone containing bone marrow formed 4w after implantation,and coral degraded partially.Conclusion Coral is a good carrier of rhBMP-2 and collagen in the complex acts as the delivery system for rhBMP-2.This complex is useful for bone defect repair because it has both bone conductive and bone inductive activity. |
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| Keywords: | rhBMP-2 Collagen Coral Bone inductive activity |
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