黄体酮联合间苯三酚治疗早期先兆流产的临床观察

目的:观察黄体酮联合间苯三酚治疗早期先兆流产的临床疗效和安全性。方法:60例早期先兆流产妊娠期妇女按随机数字表法均分为对照组和观察组。对照组妊娠期妇女给予黄体酮40 mg,肌肉注射,bid;观察组妊娠期妇女在对照组治疗的基础上给予间苯三酚80 mg加入5%葡萄糖注射液250 ml中静脉滴注,qd。两组妊娠期妇女疗程均为7 d。观察两组妊娠期妇女的保胎成功率和治疗前、后血孕酮水平,记录临床症状缓解时间、消失时间及不良反应发生情况。结果:观察组妊娠期妇女保胎成功率显著高于对照组妊娠期妇女,两组比较差异有统计学意义(P<0.05);观察组妊娠期妇女临床症状缓解时间和消失时间均显著短于对照组妊娠期妇女,两组比较差异有统计学意义(P<0.05);治疗后两组妊娠期妇女血孕酮水平均显著高于同组治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。两组妊娠期妇女不良反应发生率比较差异无统计学意义(P>0.05)。结论:黄体酮联合间苯三酚治疗早期先兆流产疗效显著,可有效缓解临床症状,提高血孕酮水平,且安全性较好。

Clinical Observation of Progesterone Combined with Phloroglucinol in the Treatment of First-trimester Threatened Abortion

OBJECTIVE： To observe clinical efficacy and safety of progesterone combined with phloroglucinol in the treatment of first-trimester threatened abortion. METHODS： 60 pregnant women with first-trimester threatened abortion were randomly divided into control group and observation group. Control group was given progesterone 40 mg, intramuscularly, bid; observation group was additionally given phloroglucinol 80 mg added into 5% Glucose injection 250 ml intravenously, qd, on the basis of control group. Treatment course of 2 groups lasted for 7 days. The rate of successful pregnancy, time of clinical symptom relief and disap- pearance and occurrence of adverse drug reaction before and after treatment were observed in 2 groups. RESULTS： The rate of suc- cessful pregnancy in observation group was significantly higher than in control group; there was statistical significance （P〈0.05）. The time of clinical symptom relief and disappearance in observation group was significantly lower then in control group; there was statistical significance （P〈0.05）. The levels of progesterone in 2 groups after treatment were significantly higher than before; that of observation group was higher than that of control group; there was statistical significance （P〈0.05）. There was no statistical significance in the incidence of adverse drug reaction in 2 groups （P〉0.05）. CONCLUSIONS： Progesterone combined with phloroglucinol is effective in the treatment of first-trimester threatened abortion, and can relieve clinical symptoms and improve serum progesterone and safety.