| 孤啡肽对内吗啡肽-1抗伤害感受作用的影响 |
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| 引用本文： | 管忍,李伟彦,徐建国,丁艳. 孤啡肽对内吗啡肽-1抗伤害感受作用的影响[J]. 医学研究生学报, 2004, 17(12): 1079-1082 |
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| 作者姓名： | 管忍 李伟彦 徐建国 丁艳 |
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| 作者单位： | 1. 南京军区南京总医院,麻醉科,江苏南京,210002
2. 南京军区南京总医院,感染控制科,江苏南京,210002 |
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| 摘 要： | 目的：观察孤啡肽对内吗啡肽-1在痛觉控制方面的影响。方法：采用侧脑室、鞘内同时注射孤啡肽和内吗啡肽-1，运用热辐射甩尾和醋酸扭体测痛，观察孤啡肽对内吗啡肽-1抗伤害感受效应的影响。结果：侧脑室注射孤啡肽可拮抗内吗啡肽-1的抗伤害感受效应，而鞘内注射孤啡肽可增强内吗啡肽-1的抗伤害感受效应。结论：孤啡肽在脊髓上和脊髓水平均可影响内阿片肽的抗伤害感受效应，但作用机制可能不同。
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| 关 键 词： | 孤啡肽-1 内吗啡肽-1 抗伤害感受作用 |
| 文章编号： | 1008-8199(2004)12-1079-04 |
| 修稿时间： | 2004-04-21 |
Effects of orphanin FQ on endomorphin-1 induced antinociception |
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| GUAN Ren ,LI Wei-yan ,XU Jian-guo ,DING Yan. Effects of orphanin FQ on endomorphin-1 induced antinociception[J]. Bulletin of Medical Postgraduate, 2004, 17(12): 1079-1082 |
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| Authors: | GUAN Ren LI Wei-yan XU Jian-guo DING Yan |
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| Affiliation: | GUAN Ren 1,LI Wei-yan 1,XU Jian-guo 1,DING Yan 2 |
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| Abstract: | Objective: To observe the effects of OFQ on endomorphin-1 in pain modulation. Methods: OFQ and endomorphin-1 were microinjected intracerebroventricularly or intrathecally in rats. The pain thresholds were measured by tail-flick test and acetic-acid induced twitching test, and the changes of antinociceptive effects induced by endomorphin-1 were observed. Results: OFQ antagonizing endomorphin-1 antinociception at the supraspinal level, while enhancing at the spinal level were observed. Conclusion: OFQ has functional effects on endomorphin-1 in pain modulation,both in the brain and the spinal cord. The mechanisms of its effect may be different. |
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| Keywords: | Orphanin FQ Endomorphin-1 Antinociceptive effect |
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