当归芍药散对小鼠免疫功能的影响

目的 研究当归芍药散(DSS)对小鼠免疫功能的作用，为临床用于老年性痴呆的防治提供一定依据。方法 采用亚急性衰老小鼠胸腺指数、2，4，6-三硝基氯苯诱导小鼠迟发性变态反应(PC—DTH)、炭粒廓清、溶血素生成及体外脾淋巴细胞增殖等实验，观察DSS对机体免疫功能的影响。结果 DSS明显升高D-半乳糖所致亚急性衰老小鼠降低的胸腺指数；显著增强醋酸泼尼松龙所致免疫抑制小鼠由2，4，6-三硝基氯苯诱导的迟发型变态反应(PC-DTH)反应能力；体外对小鼠脾淋巴细胞增殖有一定促进作用；而对正常及免疫功能抑制小鼠炭粒廓清及溶血素生成均无明显影响。结论 当归芍药散对免疫系统具有一定选择性作用，主要增强细胞免疫功能。

Effect of DSS on immune function in mice

OBJECTIVE The effects of DSS on the immune function in mice were observed so as to provide some evidence for its therapeutic application in senile dementia. METHOD A series of experiments were performed to show the effects of DSS on immune function, including thymus index determination in aged mice induced by D galactose(D gal), delayed type hypersensitivity induced by picryl chloride( PC DTH), carbon clearance and hemolysin detection in vivo and lymphocyte proliferation in vitro .RESULTS DSS significantly increased thymus index suppressed by D gal, enhanced PC DTH inhibited by Pred, and stimulated lymphocytes proliferation in vitro . Meanwhile DSS had no markable effect on carbon clearance and hemolysin production in normal and immunosuppressed mice.CONCLUSION DSS had the selective regulation on immune system, and mainly affected cellular immunity, which is beneficial for its therapeutic application in senile dementia.