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Suppression of conditioned avoidance by 8-OH-DPAT in the rat
Authors:Marie -Louise Wadenberg  S. Ahlenius
Affiliation:(1) Department of Psychology, University of Stockholm, Stockholm;(2) Present address: Department of Neuropharmacology, Astra Research Centre, Södertälje, Sweden
Abstract:Summary Rats were trained to perform an aversely motivated discriminative task in a shuttle-box. The conditioned avoidance response was selectively suppressed by 8-OH-DPAT in a dose-dependent manner (25–100 mgrg·kg–1). There were no statistically significant deficits in discriminative performance. The present results suggest antipsychotic-like properties of 8-OH-DPAT.
Keywords:8-OH-DPAT  conditioned avoidance  rat
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