| 碱性成纤维细胞生长因子在糖尿病大鼠视网膜病变中的表达 |
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| 引用本文： | 宋鄂,施小茹,常秀琴,吴家祥. 碱性成纤维细胞生长因子在糖尿病大鼠视网膜病变中的表达[J]. 吉林大学学报(医学版), 2003, 29(2): 147-148,160,F001 |
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| 作者姓名： | 宋鄂 施小茹 常秀琴 吴家祥 |
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| 作者单位： | 吉林大学第一医院眼科,吉林,长春,130021;吉林大学第一医院理疗科;吉林大学基础医学院病理教研室 |
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| 基金项目： | 吉林省科研项目;吉科会字第990575-5号; |
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| 摘 要： | 目的 :探讨碱性成纤维细胞生长因子 ( b FGF)在糖尿病大鼠视网膜中的表达情况。方法 :建立糖尿病大鼠动物模型后 1、3、5个月进行视网膜石蜡切片的原位杂交及免疫组化实验。结果 :b FGFm RNA从 3个月开始有表达 ( 78% ) ,5个月时增加至 89% ,b FGF蛋白质也从 3个月开始有表达 ( 5 6% ) ,5个月时增至 89%。结论 :b FGF在糖尿病大鼠背景期的视网膜病变中有表达
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| 关 键 词： | 糖尿病视网膜病 碱性成纤维细胞生长因子 原位杂交 免疫组织化学 |
| 文章编号： | 1671-Ⅹ587(2003)02-0147-02 |
Expression of Basic-Fibroblast Growth Factor in Retina of Diabetic Rats |
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| SONG E ,SHI Xiao ru ,CHANG Xiu qin ,WU Jia xiang. Expression of Basic-Fibroblast Growth Factor in Retina of Diabetic Rats[J]. Journal of Jilin University: Med Ed, 2003, 29(2): 147-148,160,F001 |
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| Authors: | SONG E SHI Xiao ru CHANG Xiu qin WU Jia xiang |
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| Affiliation: | SONG E 1,SHI Xiao ru 1,CHANG Xiu qin 2,WU Jia xiang 3 |
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| Abstract: | Objective:To study the expression of Basic Fibroblast Growth Factor (b FGF) in retina of diabetic rats. Methods:After diabetic rat models were established with streptozocin,in situ hybridization and immunohistochemistry were carried out on paraffin slide at 1,3 and 5 month, respectively.Results:In situ hybridization showed expression of mRNA of bFGF from diabetic rats. The expression rate increased up to 89% until 5 months. Immunohistochemcally, bFGF expression also was showed in paraffin slide. The rate increased to 56% in diabetic rats after 3 months, to 89% for 5 months. Conclusion:The bFGF could be expressed in background diabetic retinopathy of diabetic rats. |
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| Keywords: | Diabetic retinopathy bFGF In situ hybridization Immunohistochemistry |
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