银花泌炎灵片联合萘哌地尔治疗慢性前列腺炎的临床研究

目的探讨银花泌炎灵片联合萘哌地尔治疗慢性前列腺炎的临床疗效。方法选取2015年1月—2015年12月无锡市人民医院收治的慢性前列腺炎患者106例,随机分为对照组和治疗组,每组各53例。对照组睡前口服萘哌地尔片,25 mg/次,1次/d。治疗组在对照组基础上口服银花泌炎灵片,4片/次,3次/d。两组患者均治疗8周。观察两组的临床疗效,比较两组残余尿量(PVR)、最大尿流率(Qmax)、平均尿流率(Qave)、巨噬细胞炎性蛋白-2(MIP-2)和超敏C反应蛋白(hs-CRP)情况。结果治疗后,对照组和治疗组的总有效率分别为69.81%、88.68%,两组比较差异有统计学意义(P0.05)。治疗后,两组PVR均显著下降,而Qmax和Qave均显著升高,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组MIP-2和hs-CRP均显著下降,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的下降程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。结论银花泌炎灵片联合萘哌地尔治疗慢性前列腺炎具有较好的临床疗效,可改善临床症状,减轻炎症反应,具有一定的临床推广应用价值。

Clinical study on Yinhua Miyanling Tablets combined with naftopidil in treatment of chronic prostatitis

Objective To investigate the clinical effect of Yinhua Miyanling Tablets combined with naftopidil in treatment of chronic prostatitis. Methods Patients (106 cases) with chronic prostatitis in Wuxi People''s Hospital from January 2015 to December 2015 were randomly divided into control and treatment groups, and each group had 53 cases. Patients in the control group were po administered with Naftopidil Tablets before bedtime, 25 mg/time, once daily. Patients in the treatment group were po administered with Yinhua Miyanling Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and PVR, Q_max, Q_ave, MIP-2, and hs-CRP in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 69.81% and 88.68%, respectively, and there was difference between two groups (P<0.05). After treatment, the PVR in two groups were significantly decreased, but Q_max and Q_ave in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, MIP-2 and hs-CRP in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Yinhua Miyanling Tablets combined with naftopidil has clinical curative effect in treatment of chronic prostatitis, can improve clinical symptoms, and relieve inflammatory reaction, which has a certain clinical application value.