脑苷肌肽联合多奈哌齐治疗阿尔茨海默病的疗效观察

目的探讨脑苷肌肽联合多奈哌齐治疗阿尔茨海默病的临床疗效。方法选取2011年3月—2015年3月巴彦淖尔市医院神经康复科收治的阿尔茨海默病患者114例,随机分为对照组(65例)和治疗组(49例)。对照组患者每晚口服盐酸多奈哌齐片,初始剂量5 mg/d,1个月后增至终剂量10 mg/d。治疗组在对照组的基础上于治疗前2周静脉滴注脑苷肌肽注射液,10 m L加入生理盐水250 m L中,1次/d。所有患者均连续治疗6个月。比较两组患者临床疗效,评估两组患者治疗前后简易智力状态检查量表(MMSE)、蒙特利尔认知评定量表(Mo CA)、日常生活能力量表(ADL)、汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评分。结果治疗后,对照组和治疗组总有效率分别为87.7%和93.9%,两组总有效率比较差异无统计学意义。治疗后,两组患者MMSE和Mo CA评分较治疗前明显升高,HAMA和HAMD评分则显著下降,且治疗组ADL评分较治疗前显著升高,同组治疗前后MMSE、Mo CA、HAMA和HAMD评分及治疗组ADL评分治疗前后比较差异具有统计学意义(P0.05)。治疗后,治疗组MMSE、Mo CA、ADL和HAMD评分比对照组治疗后改善更显著,两组比较差异具有统计学意义(P0.05)。结论脑苷肌肽联合多奈哌齐治疗可改善阿尔茨海默病患者的认知功能、日常生活能力和焦虑抑郁情绪。

Clinical observation of cattle encephalon glycoside and ignotin combined with donepezil in treatment of Alzheimer's disease

Objective To explore the clinical effect of cattle encephalon glycoside and ignotin combined with donepezil in treatment of Alzheimer''s disease. Methods Patients (114 cases) with Aalzheimer''s disease in Department of Neurological Rehabilitation of Inner Mongolia Bayannaoer City Hospital from March 2011 to March 2015 were randomly divided into the control (65 cases) and treatment (49 cases) groups. Patients in the control group were po administered with Donepezil Hydrochloride Tablets every night, and the initial dosage was 5 mg/d, and which was gradually increased to 10 mg/d after 1 month. Patients in the treatment group were iv administered with Cattle Encephalon Glycoside and Ignotin Injection on the basis of the control group for 2 weeks before treatment, 10 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacy was compared, and MMSE, MoCA, ADL, HAMA, and HAMD scores before and after treatment in two groups were assessed. Results After treatment, the clinical efficacy in the control and treatment group was 87.7% and 93.9%, respectively, and there were no differences between two groups. After treatment, MMSE and MoCA scores in two groups were significantly increased, HAMA and HAMD scores were significantly decreased, and ADL scores in the treatment group were significantly increased, and the difference was statistically significant in the same group (P<0.05). And compared with the control group, the scores of MMSE, MoCA, ADL, and HAMD in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Cattle encephalon glycoside and ignotin combined with donepezil can improve the cognitive function, daily living ability, anxiety and depression in treatment of Alzheimer''s disease.