Quantitative analysis of immunocompetent cells in human normal oral and uterine cervical mucosa, oral papillomas and leukoplakias |
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| Authors: | J Becker J Behem T L?ning P Reichart H Geerlings |
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| Institution: | 1. Abteilung für zahnärztliche Chirurgie, Oralchirurgie Polikliniken für Zahn-, Mund- und Kieferkrankheiten-Nord, Freie Universität Berlin, Föhrer Str. 15, 1000 Berlin 65, FRG;2. Institut für Pathologie der Universität Hamburg, 2000 Hamburg 20, FRG;3. Institut für Biometrie der Medizinischen Hochschule, 3000 Hannover 61, FRG;1. Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark;2. Alexion, AstraZeneca Rare Disease, Boston, MA, USA;3. Department of Nuclear Medicine & PET-center, Aarhus University Hospital, Aarhus, Denmark;4. Department of Biomedicine, Aarhus University, Aarhus, Denmark;5. Department of Medicine, Section of Digestive Diseases, and Department of Surgery, Section of Transplant and Immunology, Yale School of Medicine, New Haven, CT, USA;1. Kasturba Medical College – Manipal, Manipal University, Karnataka 576104, India;2. Medical Mycology Division, Department of Microbiology, Kasturba Medical College – Manipal, Manipal University, Karnataka 576104, India;3. Department of Medicine, Kasturba Medical College – Manipal, Manipal University, Karnataka 576104, India;4. Department of Microbiology, Kasturba Medical College – Manipal, Manipal University, Karnataka 576104, India;1. Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, MD, USA;2. Preventive Dental Sciences Department, School of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia;1. Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, MD 21287, USA;2. Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21287, USA;3. Department of Oncology, Johns Hopkins University, Baltimore, MD 21287, USA;4. Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA;5. Department of Pharmacology, Oxford University, Oxford OX1 3QT, UK;6. Baltimore Veterans Administration Medical Center, Baltimore, MD 21201, USA;1. Graduate Program in Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil;2. Private Dental Practioner, Pelotas, RS, Brazil;3. Department of Dentistry. Federal University of Juiz de Fora, Governador Valadares, MG, Brazil |
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| Abstract: | Using monoclonal antibodies reacting with T-cell subpopulations, Langerhans cells and macrophages, the number and distribution of cells of the immune system in normal oral and cervical mucosa was determined and statistically compared with that in oral papillomas and oral leukoplakias. Increased numbers of labelled cells were found in oral leukoplakias and particularly in oral papillomas. In the epithelium of all specimens, Langerhans cells and T-lymphocytes of the suppressor/cytotoxic phenotype as well as of the helper phenotype were seen. Suppressor/cytotoxic and helper T-lymphocytes were in equal numbers in the epithelium of oral papillomas, but were about 2:1 in all other lesions. In normal oral epithelium, macrophages were rare but were in greater numbers in leukoplakias and papillomas. In the connective tissue of all lesions, more labelled cells were present than in epithelium with T-lymphocytes predominant. Although Langerhans cells were rare in connective tissue, many were seen in oral papillomas. |
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