急性心肌梗死病人CRP及CK-MB测定及其意义

①目的探讨急性心肌梗死病人外周血中C反应蛋白（CRP）和肌酸激酶同工酶（CK—MB）含量变化与冠心病病理变化过程、病情进展和转归的关系。②方法对40例急性心肌梗死病人发病后不同时间和冠状动脉支架安置术后6h外周血中CRP和CK—MB含量分别进行检测并与正常对照组进行比较。③结果急性心肌梗死病人发病6～14h血清中CRP和CK—MB含量明显升高，与对照组比较差异有显著性（t=2．065～2．740，P〈0．05）。冠状动脉支架安置术后外周血中CRP和CKMB含量与急性心肌梗死发病后14h相比明显减低，差异有显著性（t=2．031、2，368，P〈0．05）。④结论急性心肌梗死发病后6h外周血中CRP和CK—MB含量即开始升高，在14h明显升高。随着治疗的干预，临床症状得到缓解，受损心肌逐渐康复，外周血中CRP和CK—MB的含量逐渐下降。因此，CRP及CK—MB含量的测定对于预测急性心肌梗死病人病情及预后有一定价值。

THE LEVELS OF CRP AND CK-MB AND THEIR SIGNIFICANCE IN PERIPHERAL BLOOD OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Objective To determine the levels of CRP and CK-MB in peripheral blood in patients with acute myocardial infarction (AMI), and to analyze the relationship between CRP and CK-MB and the pathologic changes and improvement of the disease. Methods This study included 40 patients with AMI and those six hours after coronary stenting. The concentrations of CRP and CK-MB were determined at different times and compared with that of the normal controls. Results The CRP and CK-MB were higher in the patients after 6-14 hours than those of the control group (t=2.065-2.740, P<0.05) .There was a significant difference between the reduction in CRP and CK-MB levels after coronary stent implantation and 14 hours after AMI onset (t=2.031, 2.368; P<0.05). Conclusion The levels of CRP and CK-MB increased at six hours after onset of the disease, and greatly increased after 14 hours. CRP and CK-MB levels were depressed and clinical symptoms relieved after the therapy. The detection of CRP and CK-MB is helpful in the judgement of the prognosis of AMI .