高血压病患者血浆降钙素基因相关肽和内皮素浓度的变化

目的 :探讨血浆降钙素基因相关肽 （CGRP）和内皮素 （ET）与高血压病之间关系。方法 :放射免疫方法检测 2 5例正常人和 36例高血压病患者降压治疗前后血浆 CGRP和 ET浓度 ,同时测量高血压病患者血压。结果 :1高血压病患者血浆 CGRP浓度低于正常人 ,与平均动脉压呈负相关 ;ET浓度高于正常人 ,与平均动脉压呈正相关。2有效降压治疗后 ,高血压病患者血浆 CGRP浓度回升 ,ET浓度下降 ,CGRP/ ET比值明显升高。结论 :血浆 CGRP和ET浓度失衡可能是高血压病发生的重要原因之一 ;有效降血压可能与 CGRP和 ET的变化有关。

Changes in plasma calcitonin gene-related peptide and endothelin concentration in patients with essential hypertension

AIM:To investingate the relationship between the plasma cal citonin gene-related peptide (CGRP),endothelin (ET) in patient with essential hypertension. METHODS:We determined the plasma concentration of CGRP and ET in 25 no rmotension people and 36 patients with essential hypertension before and after a nti-hypertension treatment with radioimmunoassay,and measured the blood pressur e of essential hypertension patients. RESULTS:①The plasma CGRP concent ration in patients with essential hypertension was lower than that in the normot ension people,and there was a negative relationship between it and the mean arte ry pressure. The plasma ET concentration in patients with essential hypertension was higher than that in the normotension people, and there was a positive relat io nship between it and the mean artery pressure. ②After effective antihypertensio n treatment,the plasma CGRP concentration in the hypertensive was elevated,the p lasma ET concentration was lowered,and the rate of CGRP/ET was elevated. C ONCLUSION:The unbalance between plasma CGRP and ET concentration might be an important reason for essential hypertension,and the effective antihypertension treatment might regulate the balance between this pair of vasoactive substances .