Recycling endosomes and TLR signaling--the Rab11 GTPase leads the way |
| |
Authors: | Kagan Jonathan C |
| |
Affiliation: | Department of Pediatrics, Division of Gastroenterology and Harvard Medical School, Children's Hospital Boston, 300 Longwood Ave, Enders 730.2, Boston, MA 02115, USA. jonathan.kagan@childrens.harvard.edu |
| |
Abstract: | The ability of Toll-like receptors (TLRs) to activate innate immunity depends on their transport to pathogen-containing organelles. In this issue of Immunity, Husebye et?al. (2010) report that delivery of TLR4 to phagosomes occurs via a recycling endosome intermediate, which is controlled by the GTPase Rab11a. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|