| 前列腺癌组织中树突状细胞的变化及以此为基础的免疫治疗 |
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| 引用本文： | 齐士勇,王萌,徐勇.前列腺癌组织中树突状细胞的变化及以此为基础的免疫治疗[J].中华男科学杂志,2007,13(5):453-456. |
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| 作者姓名： | 齐士勇 王萌 徐勇 |
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| 作者单位： | 天津市泌尿外科研究所前列腺疾病研究室,天津,300211 |
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| 摘 要： | 树突状细胞(DC)作为功能最为强大的抗原呈递细胞,对肿瘤免疫起着关键的启动作用。前列腺癌细胞通过一系列复杂的作用使肿瘤免疫微环境中DC的数目和功能发生变化,从而逃逸机体的免疫监视,形成了肿瘤的发生、发展。认识到这一点,人们开展以DC为基础的前列腺癌的免疫疫苗治疗,并取得了一定的效果。而前列腺癌免疫微环境中DC的变化和以此为基础的免疫治疗仍处于起步阶段。
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| 关 键 词： | 前列腺癌 树突状细胞 免疫微环境 疫苗 |
| 文章编号： | 1009-3591（2007）05-0453-04 |
| 收稿时间： | 2006-06-06 |
| 修稿时间： | 2006-06-062006-09-06 |
Changes of Dendritic Cells in Prostate Cancer and Dendritic Cell-based Immunotherapy |
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| QI Shi-yong,WANG Meng,XU Yong.Changes of Dendritic Cells in Prostate Cancer and Dendritic Cell-based Immunotherapy[J].National Journal of Andrology,2007,13(5):453-456. |
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| Authors: | QI Shi-yong WANG Meng XU Yong |
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| Institution: | Research Laboratory of Prostate Diseases, Tianfin Urology Institute, Tianfin 300211, China |
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| Abstract: | As the potent professional antigen present cell,dendritic cells(DC)play an important role in the initiation for anti-tumor immunity.Prostate cancer(PCa)can reduce the number and function of tumor infiltrated dendritic cells(TIDC)by a series of complicated mechanisms,escaping from immunosurveillance.With the development of immunology,more and more studies focus on TIDC and DC-based vaccines for PCa.However,all these studies are still at the exploratory stage.Here is a review of the related literature. |
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| Keywords: | prostate cancer dendritic cell immunomicroenviroment vaccine |
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