Agranulocytosis following infectious mononucleosis |
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Authors: | S. Sumimoto Y. Kasajima T. Hamamoto T. Miyanomae Y. Iwai M. Mayumi H. Mikawa |
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Affiliation: | (1) Department of Paediatrics, Sumitomo Hospital, 2-2 5-Chome, Nakanoshima, Osaka, Japan;(2) Department of Paediatrics, Kyoto University Hospital, Kyoto, Japan |
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Abstract: | A girl developed acute agranulocytosis (45/mm3), 37 days after the onset of infectious mononucleosis. The bone marrow showed myeloid hyperplasia with maturation arrest and erythroid hypoplasia. A normal amount of colony forming units of granulocytes and macrophages (CFU-GM) colonies with a relative high number of clusters was observed. Neither anti-neutrophil antibodies nor circulating inhibitors of colony growth were found in serum. Granulocyte and macrophage colony stimulating factor (GM-CSF) activity in the patient's serum rose at this time. The agranulocytosis lasted 5 days and her clinical state soon improved. These results suggested that agranulocytosis was presumably not due to serum factors, including auto-antibodies and/or suppressive substances, and that Epstein-Barr virus (EBV) had some direct or indirect effect on the marrow cells of the myeloid series. |
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Keywords: | Agranulocytosis Infectious mononucleosis GM-CSF CFU-GM |
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