前列疏胶囊对实验性前列腺增生模型的影响

目的:观察中药复方前列疏胶囊对实验性前列腺增生动物模型的影响。方法:采用前列腺腹叶植入3个16 d胎龄胎鼠尿生殖窦组织致小鼠前列腺增生模型以及去势大鼠皮下注射丙酸睾丸素2.5 mg.kg-140 d致大鼠前列腺增生模型,给药30 d,观察前列腺重量、脏器指数、腺腔面积及病理组织学改变。结果:小鼠模型前列疏胶囊各组可明显降低前列腺重量和脏器指数(P<0.01),中、高剂量组能明显缩小前列腺腺腔面积(P<0.01,P<0.05);大鼠模型前列疏胶囊各剂量组前列腺重量明显下降(P<0.01)、脏器指数降低(P<0.01),前列腺腺腔面积明显缩小(P<0.05~0.01)。病理组织学检查显示,前列疏胶囊对两种前列腺增生模型病理组织学改变有减轻作用。结论:前列疏胶囊有较好的抗前列腺增生作用。

Effect of Qianlieshu Capsule on the Experimental Prostatic Hyperplasia

Objective:To study the effect of Qianlieshu Capsule on experimental prostatic hyperplasia.Methods: The animal model of prostatic hyperplasia was established by fetal urogenital sinus implanting in ventral prostates.Wistar Rats were administered testosterone propionate 2.5 mg·kg^-1 subcutaneously for 40 days after orchiectomy,and Qianlieshu was given in different dosages for 30 days.The prostate weight,index,lumens areas and pathological changes were observed.Results: Qianlieshu Capsule can obviously decrease prostate weight and index in mice,reduce prostatic lumens areas were only found in middle and high dosages.Decrease prostate weight,index and prostatic lumens areas were observed in rat.The pathological changes were reduced.Conclusion: Qianlieshu Capsule has significant anti-benign prostatic hyperplasia actions.