Neural network-based alterations during repetitive heat pain stimulation in major depression |
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| Institution: | 1. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;2. Department of Neurophysiology, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;1. Deparment of Neuroscience, University of the Basque Country (UPV/EHU), Barrio Sarriena s/n, Leioa 48940, Bizkaia, Spain;2. Deparment of Pharmacology, University of the Basque Country (UPV/EHU), Leioa, Spain;3. Nanoneurosurgery Group, BioCruces Bizkaia Health Research Institute, Barakaldo, Spain;4. Neurodegenerative Diseases group, BioCruces Bizkaia Health Research Institute, Barakaldo, Spain;5. Faculty of Health Science, Universidad Autónoma de Chile, Santiago de Chile, Chile;1. Department of Chinese Medicine, China Medical University Hospital, Taichung 404, Taiwan;2. School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan;3. Research Center for Traditional Chinese Medicine, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan;4. Research Center for Chinese Herbal Medicine, China Medical University, Taichung 404, Taiwan;5. Chinese Medicine Research Center, China Medical University, Taichung 404, Taiwan;6. Department of Biotechnology, Asia University, Taichung 413, Taiwan;7. Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan;8. Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan;1. Mood Disorders Psychopharmacology Unit (MDPU), University Health Network, University of Toronto, Toronto, Canada;2. University of Toronto, Toronto, Canada;3. Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, USA;4. Reference Center for Alcohol, Tobacco and Other Drugs (CRATOD), São Paulo State Secretariat of Health, São Paulo, SP, Brazil;5. Endocrinology & Metabolism Division, Sunnybrook Health Sciences Centre, University of Toronto, Canada;6. Department of Affective Disorders, the Affiliated Hospital of Guangzhou Medical University and GMU-HKU Mood and Brain Sciences Center, Guangzhou, China;7. Psychiatric Center Copenhagen, University of Copenhagen, Copenhagen, Denmark;8. Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;9. Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil;10. Research Group in Molecular and Behavioral Neuroscience of Bipolar Disorder, Departament of Psychiatry, Universidade Federal de São Paulo, SP, Brazil;1. Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, The Netherlands;2. Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, The Netherlands;3. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA;4. Ter Gooi Hospital, Department of Psychiatry, Blaricum, The Netherlands;5. Department of Psychology, Utrecht University, Utrecht, The Netherlands;6. Department of Medical Genetics, University Medical Centre Utrecht, Utrecht University, The Netherlands;7. MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK;8. UCLA Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA;9. Neuroimmunology, Netherlands Institute for Neuroscience, An institute of the royal academy of arts and sciences, Amsterdam, The Netherlands;1. School of Psychological Sciences, Tel Aviv University, Tel-Aviv, Israel;2. Department of Life Sciences and the Zlotowski Center for Neuroscience, Ben-Gurion University, Be''er-Sheva, Israel;3. Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel;1. Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123 Allschwil, Switzerland;2. Centre for Human Drug Research (CHDR), Zernikedreef 8, 2333 CL Leiden, the Netherlands |
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| Abstract: | The current study aimed to identify alterations in brain activation and connectivity related to nociceptive processing and pain sensitization in major depressive disorder (MDD), using repetitive heat pain stimulation during functional magnetic resonance imaging (fMRI) in 37 MDD patients and 33 healthy controls. Regional activation did not differ between groups, but functional connectivity was significantly decreased in MDD in a neural network connecting frontal, temporal and occipital areas (family-wise error-corrected pFWE = 0.045). Supporting analyses suggested a significant association between network connectivity and trait neuroticism (p = 0.007) but not with the clinical state or familiar risk of MDD (all p values > 0.13). Our data relate a network-based phenotype for altered pain processing and antinociceptive control to MDD and encourage future studies on the shared intermediate neural psychological risk architecture of MDD and chronic pain. |
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