Altered amygdala subregion-related circuits in treatment-naïve post-traumatic stress disorder comorbid with major depressive disorder |
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| Institution: | 1. Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, China;2. Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu, China;3. Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, United States;4. Department of Psychiatry, Columbia University, New York, NY, United States;5. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China;6. Radiology Department of the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China;7. Department of Radiology, Columbia University College of Physicians and Surgeons, New York, NY;1. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China;2. Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China;3. Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China;4. Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China;5. Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China;6. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, Sichuan, China;7. Department of Psychology, School of Public Administration, Sichuan University, Chengdu 610041, Sichuan, China;8. Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, China;1. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China;2. Department of Radiology, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China;3. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, OH, USA;4. Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, Sichuan, China;5. Department of Psychology, School of Public Administration, Sichuan University, Chengdu, Sichuan, China;1. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA;2. Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA;3. Department of Psychiatry, Faculty of Medicine, Minia University, Egypt;4. Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA;5. Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;6. Department of Radiology, Columbia University College of Physicians and Surgeons, New York, NY, USA;1. Department of Radiology, West China Hospital of Sichuan University, No 37, Guoxue Alley, Chengdu 610041, China;2. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China;3. Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, China;4. Mental Health Center and Psychiatric Laboratory, The State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, China;5. Department of Psychiatry, The Mental Health Center of Sichuan, Mianyang, China;6. Department of Psychiatry, Zigong Mental Health Center, Zigong, China;7. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA |
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| Abstract: | Individuals with both post-traumatic stress disorder and major depressive disorder (PTSD+MDD) often show greater social and occupational impairment and poorer treatment response than individuals with PTSD alone. Increasing evidence reveals that the amygdala, a brain region implicated in the pathophysiology of both of these conditions, is a complex of structurally and functionally heterogeneous nuclei. Quantifying the functional connectivity of two key amygdala subregions, the basolateral (BLA) and centromedial (CMA), in PTSD+MDD and PTSD-alone could advance our understanding of the neurocircuitry of these conditions. 18 patients with PTSD+MDD, 28 with PTSD-alone, and 50 trauma exposed healthy controls (TEHC), all from a cohort who survived the same large earthquake in China, underwent resting-state functional magnetic resonance imaging. Bilateral BLA and CMA functional connectivity (FC) maps were created using a seed-based approach for each participant. The analysis of covariance of FC was used to determine between-group differences. A significant interaction between amygdala subregion and diagnostic group suggested that differences in connectivity patterns between the two seeds were mediated by diagnosis. Post-hoc analyses revealed that PTSD+MDD patients showed weaker connectivity between right BLA and (a) left anterior cingulate cortex/supplementary motor area, and (b) bilateral putamen/pallidum, compared with PTSD-alone patients. Higher CMA connectivities left ACC/SMA were also observed in PTSD+MDD compared with PTSD-alone. An inverse relationship between the connectivity of right BLA with right putamen/pallidum and MDD symptoms was found in PTSD+MDD. These findings indicate a relationship between the neural pathophysiology of PTSD+MDD compared with PTSD-alone and TEHC and may inform future clinical interventions. |
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