Epithelioid hemangioma of bone: A unique case with multifocal metachronous bone lesions期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Epithelioid hemangioma of bone: A unique case with multifocal metachronous bone lesions

Affiliation:	1. Laboratory for Orthopedic Pathophysiology and Regenerative Medicine, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136, Bologna, Italy;2. Department of Pathology, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136, Bologna, Italy;3. Department of Biomedical and Neuromotor Science, University of Bologna, Via Foscolo 7, 40132, Bologna, Italy;4. Department of Orthopaedic Surgery, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136, Bologna, Italy;1. Department of Orthopaedics, Nizam''s Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India;2. Department of Biochemistry, Nizam''s Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India;1. Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA;2. Department of Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA;3. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA

Abstract:	Epithelioid hemangioma of bone is a rare vascular neoplasm with a ubiquitous distribution. To date, up to 25% epithelioid hemangioma of bone presents synchronous bone lesions. We report a unique case of epithelioid hemangioma with multifocal metachronous bone lesions without any fatal outcome observed after a long period. Importantly, a strong nuclear expression of FOSB antibody was detected by immunohistochemical analysis. In this case, the pathologic and radiologic findings are also described. We suggest that epithelioid hemangioma can present multifocal metachronous bone lesions without producing a fatal outcome.

Keywords:	Bone vascular tumors Epithelioid hemangioma Epithelioid hemangioendothelioma Multifocality Multicentricity Metastatic disease Genetic Metachronous bone lesions Synchronous bone lesions Immunohistochemical analysis FOSB antibody
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