Role of Platelet Transfusion in the Reversal of Anti-Platelet Therapy |
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| Institution: | 1. Division of Hematology/Oncology, UT Southwestern Medical Center, Dallas, TX;2. Division of Transfusion Medicine and Hemostasis, UT Southwestern Medical Center, Dallas, TX;1. Department of Hematology and Oncology, Beijing Huairou Hospital, Beijing, China;2. Department of Hematology and Oncology, Laoshan Branch of No. 401 Hospital of Chinese People''s Liberation Army (PLA), Qingdao, China;3. Department of Hematology, Chinese PLA General Hospital, Beijing, China;1. Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, ON, Canada;2. Department of Medicine, McMaster University, Hamilton, ON, Canada;3. Canadian Blood Services, BC & Yukon Centre, Vancouver, BC, Canada;4. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada;1. School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia;2. Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia;3. Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia;6. Departments of Pharmacology and Medicine, University of Toronto, Toronto, ON, Canada;1. Research and Development, Australian Red Cross Blood Service, Brisbane, Australia;2. School of Biomedical Science, Faculty of Health, Queensland University of Technology, Brisbane, Australia;3. Australian Centre for Blood Diseases, Monash University, Australia |
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| Abstract: | Antiplatelet therapy is extensively used in the primary and secondary prophylaxis of arterial thrombotic disorders. Aspirin, the most commonly used antiplatelet agent, is a cyclooxygenase−1 inhibitor and considered a mild to moderate inhibitor of platelet function. Therefore, often a second antiplatelet agent is necessary in certain clinical conditions requiring greater inhibition of platelet function. An adenosine diphosphate (ADP) receptor, P2Y12, is an important target for this purpose; several agents inhibit this receptor providing potent antiplatelet effect. One of the side effects of these agents is bleeding, which in some patients may require reversal of antiplatelet effect. Similarly, patients undergoing emergent surgeries may benefit from reversal of antiplatelet effect to avoid excessive surgical bleeding. This article reviews current literature on this topic. |
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