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Identification of CDK6 and RHOU in Serum Exosome as Biomarkers for the Invasiveness of Non-functioning Pituitary Adenoma
Authors:Yu Shan  Wang Xiaoshuang  Cao Kaican  Bao Xinjie  Yu Jia
Affiliation:1. State Key Laboratory of Medical Molecular Biology & Key Laboratory of RNA and Hematopoietic Regulation & Department of Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing 100005, China;2. Department of Thoracic Surgery, Nanfang Hospital, Guangzhou 510515, China;3. Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;1. Department of Radiology, Beijing 100730, China;2. Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China;1. College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, MIIT Key Laboratory of Pattern Analysis and Machine Intelligence, Nanjing 211106, China;2. Department of Geriatrics, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China;1. Sixth Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China;2. Department of Rheumatology, First Affiliated Hospital of China Medical University, Shenyang 110001, China;3. China Medical University, Shenyang 110013, China;1. School of Computing Science and Engineering, Central South University, Changsha 410083, China;2. School of Literature and Journalism, Central South University, Changsha 410083, China;3. Hunan Province Engineering Technology Research Center of Computer Vision and Intelligent Medical Treatment, Changsha 410083, China;1. Department of Anesthesiology and Pain Therapy, Inselspital, Bern University Hospital, University of Bern, Switzerland;2. Chronic Pain Management, Lindenhof Hospital, Lindenhof Group Bern, Switzerland;3. CTU Bern, and Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland;4. Applied Health Research Centre (AHRC), Li Ka Shing Knowledge Institute of St. Michael''s Hospital, Department of Medicine, University of Toronto, Canada;5. Centre of Sensory Motor Interaction SMI, School of Medicine, University of Aalborg, Denmark;6. Department of Anesthesiology and Pain Medicine, University of Washington, Seattle WA, USA
Abstract:Objective To explore circulating biomarkers for screening the invasiveness of non-functioning pituitary adenomas (NF-PAs).
Keywords:pituitary adenoma  invasiveness  exosome  droplet digital PCR  biomarkers  RHOU  CDK6
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