Randomized double-blind clinical trial evaluation of bone healing after third molar surgery with the use of leukocyte- and platelet-rich fibrin |
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| Affiliation: | 1. Director of the Department of Oral Surgery, Hospital Casa Salud, Valencia, Spain;2. Professor, Master Degree Program in Oral Surgery and Implantology; Associate Professor, Department of Oral Surgery; Faculty of Dentistry, University of Barcelona, Barcelona; Researcher, Institut d’Investigació Biomèdica de Bellvitge, Barcelona, Spain;3. Director, Master Degree Program in Oral Surgery and Implantology; Professor, Department of Oral Surgery; Faculty of Dentistry, University of Barcelona; Researcher, Institut d’Investigació Biomèdica de Bellvitge, Barcelona, Spain;4. Chairman and Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Barcelona; Coordinating Investigator, Institut d’Investigació Biomèdica de Bellvitge; Head, Department of Oral and Maxillofacial Surgery, Teknon Medical Center, Barcelona, Spain;1. Senior Lecturer, Department of Oral and Maxillofacial Surgery, PMS College of Dental Sciences and Research, Trivandrum, Kerala, India;2. Former Professor, Department of Oral and Maxillofacial Surgery, PMS College of Dental Sciences and Research, Trivandrum, Kerala, India;3. Professor and Head of Department, Department of Oral and Maxillofacial Surgery, PMS College of Dental Sciences and Research, Trivandrum, Kerala, India;1. Associate Professor, Orofacial Reconstruction and Regeneration Laboratory, Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Southwest Medical University, Luzhou, China;2. Attending, Orofacial Reconstruction and Regeneration Laboratory, Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Southwest Medical University, Luzhou, China;3. Associate Professor, Orofacial Reconstruction and Regeneration Laboratory, Department of Orthodontics, Hospital of Stomatology, Southwest Medical University, Luzhou, China;4. Assistant, Orofacial Reconstruction and Regeneration Laboratory, Southwest Medical University, Luzhou, China;6. Professor, Orofacial Reconstruction and Regeneration Laboratory, Department of Periodontal and Mucosal Diseases, Hospital of Stomatology, Southwest Medical University, Luzhou, China;1. Research Assistant, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Marmara University, Istanbul, Turkey;2. Research Assistant, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Marmara University, Istanbul, Turkey;3. Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Marmara University, Istanbul, Turkey;1. Resident, Division of Oral Surgery and Implantology, Department of Head and Neck, Oral Surgery, and Implantology Unit, Institute of Clinical Dentistry, Fondazione Policlinico Universitario A. Gemelli IRCCS—Università Cattolica del Sacro Cuore, Rome, Italy;2. Private Practitioner, Private Dental Practice, Ascoli Piceno, Italy;3. Resident, Division of Oral Surgery and Implantology, Department of Head and Neck, Oral Surgery, and Implantology Unit, Institute of Clinical Dentistry, Fondazione Policlinico Universitario A. Gemelli IRCCS—Università Cattolica del Sacro Cuore, Rome, Italy;4. Private Practitioner, Division of Oral Surgery and Implantology, Department of Head and Neck Oral Surgery, and Implantology Unit, Institute of Clinical Dentistry, Fondazione Policlinico Universitario A. Gemelli IRCCS—Università Cattolica del Sacro Cuore, Rome, Italy;5. Department Head, Division of Oral Surgery and Implantology, Department of Head and Neck Oral Surgery, and Implantology Unit, Institute of Clinical Dentistry, Fondazione Policlinico Universitario A. Gemelli IRCCS—Università Cattolica del Sacro Cuore, Rome, Italy |
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| Abstract: | The objective of this study was to evaluate the use of leukocyte- and platelet-rich fibrin (L-PRF) in bone healing after mandibular third molar extraction. In this prospective, double-blind, split-mouth study, 34 extractions were performed. On one side, the socket was sutured primarily (control side); on the other side, L-PRF was inserted before suturing. The patients were assessed for postoperative bone regeneration, pain and soft tissue healing. The primary outcome was bone regeneration, which was performed through tomographic evaluation in the immediate postoperative period and 3 months after the procedure. The ITK-SNAP software was used for image evaluation by the intensity of grey of each voxel. Pain was analysed using a visual analogue scale (VAS), and soft tissue healing was analysed both based on the modified healing index of Landry et al., and by comparing pre- and postoperative periodontal probing at the distal of the lower second molar. The application of L-PRF improved bone density, which was higher in test group (p = 0.007). There was no statistical difference related to pain or soft tissue between the groups (p > 0.05). There was evidence for improved bone healing in response to L-PRF. However, to better understand the effect of L-PRF more clinical trials with larger samples are necessary. |
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| Keywords: | third molar surgery platelet-rich fibrin pain bone healing |
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