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| HPLC法测定硝苯地平阿替洛尔缓释双层片中2组分含量 | |
| 引用本文： | 王中彦,唐星,侯景刚,潘春明,魏晓军. HPLC法测定硝苯地平阿替洛尔缓释双层片中2组分含量[J]. 沈阳药科大学学报, 2002, 19(1): 38-40 |
| 作者姓名： | 王中彦 唐星 侯景刚 潘春明 魏晓军 |
| 作者单位： | 1. 沈阳药科大学药学院,辽宁,沈阳,110016 2. 沈阳药业股份有限公司,辽宁,沈阳,110043 3. 沈阳市公安医院,辽宁,沈阳,110004 |
| 摘 要： | 目的测定硝苯地平阿替洛尔缓释双层片中 2组分含量。方法采用ODS(Hypersil,5 μm,4 6mm× 2 0 0mm)为填充剂 ,甲醇 水 磷酸 ( 70∶30∶0 1 )流动相的高效液相色谱法。结果硝苯地平和阿替洛尔线性分别为 0 4 0～ 1 2 0 μg ,0 80～ 2 38μg;回收率分别为 99 8%(RSD =1 0 %) ,99 9%(RSD =0 5 %)。结论该方法为评价该制剂的质量提供了可靠的方法 |
| 关 键 词： | 硝苯地平 阿替洛尔 缓释双层片 高效液相色谱法 |
| 文章编号： | 1006-2858(2002)01-0038-03 |
| 修稿时间： | 2001-05-14 |
Quantitative determination of nifedipine and atenolol in their sustained release two-layer tablets by HPLC |
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| WANG Zhong yan ,TANG Xing ,HOU Jing gang ,PAN Chun ming ,WEI Xiao jun. Quantitative determination of nifedipine and atenolol in their sustained release two-layer tablets by HPLC[J]. Journal of Shenyang Pharmaceutical University, 2002, 19(1): 38-40 | |
| Authors: | WANG Zhong yan TANG Xing HOU Jing gang PAN Chun ming WEI Xiao jun |
| Affiliation: | WANG Zhong yan 1,TANG Xing 1,HOU Jing gang 2,PAN Chun ming 2,WEI Xiao jun 3 |
| Abstract: | Objective Selecting a method is to determine nifedipine and atenolol in their sustained release two layer tablets.Method A method was establised for the quantitative determination of nifedipine and atenolol in their sustained release two layer tablets by HPLC. With a 4 6 mm×200 mm column packing of 5 μm Spherisorb C 18 used as the stationary phase,a mixture of methanol,water and phosphoric acid(70∶30∶0 1) used as the mobile phase.Result The method had a good linearity and correlation coefficient:nifedipine was between 0 40～1 20 μg,atenolol was between 0 80～ 2 38 μg .The recoveries were 99 7% and 99 9%,RSD was 0 84% and 0 43% respectively.Conclusion The method can evaluate well and truly quality of this preparation. |
| Keywords: | nifedipine atenolol sustained release two layer tablets HPLC |
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