Ultrasmall bimodal nanomolecules enhanced tumor angiogenesis contrast with endothelial cell targeting and molecular pharmacokinetics |
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Authors: | Xue Li Menglin Wu Jiahui Wang Yan Dou Xiaoqun Gong Yajuan Liu Qi Guo Xuening Zhang Jin Chang Yuanjie Niu |
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Affiliation: | 1. Department of Radiology, Second Hospital of Tianjin Medical University, Tianjin, PR China;2. School of Life Science, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, PR China;3. Sex Hormone Research Center, Tianjin Institute of Urology, Tianjin, China |
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Abstract: | Nonintrusive and precise imaging for tumor angiogenesis is critical in accurate assessment of cancer diagnosis and prognosis. However, reticulo-endothelial system (RES) capture and inadequate accumulation remain major bottlenecks for current nanoparticle to retain at tumor angiogenesis site. Herein, we report the ultrasmall contrast agent (cNGR-Au:Gd@GSH NMs) could accumulate at tumor vasculature site and enhance the tumor angiogenesis-contrast. It is demonstrated that by loading Au and Gd atom into the naturally-occurring glutathione (GSH) shell with cNGR peptide modification, cNGR-Au:Gd@GSH NMs exhibit the high X-ray photon absorption, longer rotational correlation time and efficient tumor vascular endothelia cell targeting. In vivo studies further indicate the cNGR-Au:Gd@GSH NMs prominently enhance tumor angiogenesis-contrast both on the computed tomography (CT) and magnetic resonance imaging (MRI) modalities by escaping the RES capture and target delivering. Our data imply that the cNGR-Au:Gd@GSH NMs may serve as the high-efficiency contrast agent to assess tumor angiogenesis in a nonintrusive technique. |
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Keywords: | Tumor angiogenesis Molecular imaging CT/MR dual-mode Ultrasmall nanoparticle Molecular pharmacokinetics |
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