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首发心血管疾病患者血脂水平与心血管疾病发病的相关性分析
引用本文:李刚.首发心血管疾病患者血脂水平与心血管疾病发病的相关性分析[J].中国医药,2014(6):792-794.
作者姓名:李刚
作者单位:浙江省绍兴市人民医院心内科,312000
摘    要:目的探讨首发心血管疾病患者血脂水平与心血管疾病发病危险的相关性。方法选取2009年11月至2012年10月浙江省绍兴市人民医院心内科收治的首发心血管疾病患者210例作为观察组,以同期体检健康的志愿者150例作为对照组,采集2组受试者清晨空腹静脉血,检测总胆固醇、三酰甘油、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白(apo)AI及apoB等血脂指标。结果观察组患者总胆固醇、三酰甘油、LDL-C及apoB分别为(6.1±0.3)、(1.9±0.8)、(3.9±1.5)、(1.4±0.7)mmol/L,对照组分别为(4.4±0.6)、(1.1±0.5)、(2.6±0.9)、(0.9±0.3)mmol/L,观察组各项指标均明显高于对照组(t=35.349、10.827、465、8.223,P〈0.05),而观察组apoA1为(1.5±0.3)mmol/L,低于对照组的(1.9±0.2)mmol/L,差异有统计学意义(t=14.225,P〈0.05);观察组和对照组受试者体重指数及HDL-C比较,差异均无统计学意义(26±3)kg/m。比(26±4)kg/m。,(1.4±0.6)mmoL/L比(1.2±0.9)mmol/L](t=1.748、1.556,均P〉0.05)。观察组210例患者中极高危50例、高危44例、中危64例、低危52例;总胆固醇、三酰甘油、LDL-C及apoB水平与心血管疾病发病的危险分级均呈显著正相关(r=0.786、0.753、0.663、0.900,均P〈0.05),apoA1与心血管疾病发病的危险分级呈显著负相关(r=-0.691,P〈0.05)。结论首发心血管疾病患者血脂指标的联合检测可作为预测心血管事件发生的重要方法.

关 键 词:血脂异常  心血管疾病  载脂蛋白

Correlation analysis of lipid levels in patients with cardiovascular disease and cardiovascular disease
Li Gang.Correlation analysis of lipid levels in patients with cardiovascular disease and cardiovascular disease[J].China Medicine,2014(6):792-794.
Authors:Li Gang
Institution:Li Gang. (Department of Cardiology, Shaoxing People's Hospital of Zhejiang Province, Shaoxing 312000, China)
Abstract:Objective To detect the lipid levels in patients with cardiovascular diseases. Methods To- tally 210 cases of first cardiovascular disease were in the observation group and 150 cases of healthy adults were in the control group. Fasting blood was taken with automatic biochemical detector for detecting total cholesterol (TC), triacylglycero] (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) , apolipoprotein AI and apolipoprotein B and other lipid parameters. Results TC, TG, LDL-C and apolipoprotein Bin observation group were (6.1 ±0.3), (1.9±0.8), (3.9±1.5), (1.4±0.7) mmol/L; they were (4.4±0.6), (1.1±0.5), (2.6±0.9), (0.9±0.3) mmol/L in the control group (P〈0.05). Apolipoprotein AI of the observation group was ( 1.5 ± 0.3 ) retool/L, which was significantly lower compared with the control group ( P 〈 0.05 ) ; body mass index and HDL-C in the two groups were not statistically significant (P 〉0.05). 210 cases in observation group were divided into very high-risk group (50 cases), high-risk group (44 cases) , risk group (64 cases) and low-risk group (52 cases). TC, TG, LDL-C and apolipoprotein B levels and the risk of cardiovascular disease had significant correlations ( r = 0. 786, 0. 753, 0. 663, 0. 900, all P 〈 0.05 ) ; apolipoprotein A1 and cardiovascular disease risk classification had a significant negative correlation ( r = - 0. 691, P 〈 0.05). Conclusion Detection of these serum lipids can be an important way as a predictor of cardiovascular events.
Keywords:Dyslipidemia  Cardiovascular disease  Apolipoprotein
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