丁基苯酞对血管性痴呆的认知功能的影响

丁基苯酞是从芹菜籽中提炼出来的一种天然药物,研究发现其具有改善脑部微循环、保护线粒体、明显增加脑缺血区的血量以及减少神经功能损害等多种药理作用。丁基苯酞能有效地改善血管性痴呆患者的认知功能,从而提高患者的生存质量,减轻社会经济负担。该文将近年来丁基苯酞在血管性痴呆的动物实验及其改善认知功能的作用机制和疗效临床研究进行综述。

Effect of Butylphthalide on Cognitive Function of Patients with Vascular Dementia

Butylphthalide,a natural drug extracted from celery seeds,can improve the microcirculation of the cerebrum,protect the mitochondria,significantly increase blood flow of ischemic regions of the brain,and reduce the damage of neurological function.Butylphthalide can also enhance cognitive function of patients with vascular dementia,so as to improve the life quality of the patients and reduce the socialeconomic burden.Here is to make a review of the mechanism of how butylphthalide enhance the cognitive function of vascular dementia patients in animal experiments and clinical studies on its therapeutic effect.