依折麦布对长期接受抗精神病药物治疗的精神病患者血脂的调节作用

目的 探讨依折麦布对长期接受抗精神病药物治疗的精神病患者血脂的调节作用.方法 将2010年4月至2013年8月乌鲁木齐市第四人民医院收治的伴有高血脂的94例精神病患者,按照随机数表法随机分为观察组和对照组,各47例.对照组接受辛伐他汀20 mg/d治疗,观察组患者服用10 mg/d辛伐他汀的同时加用依折麦布10 mg/d.治疗8周后对2组患者血脂及血液流变学指标进行对比分析.结果 经治疗,除载脂蛋白A外2组患者的血脂水平均有不同程度的降低（P＜0.05）,其中观察组治疗后总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白B均低于对照组（5.0±0.8） mmol/L比（5.2±0.7）mmol/L、（1.6±0.8）mmol/L比（1.9 ±0.8）mmol/L、（1.11±0.34） mmol/L比（1.07±0.49） mmol/L、（2.42±0.83） mmol/L比（3.08±0.67） mmol/L、（1.15-±0.31） g/L比（1.34 ±0.49）g/L]（均P＜0.05）.观察组和对照组患者的血液黏度（高切全血黏度、低切全血黏度及血浆黏度）较治疗前有所降低观察组：（4.2 ±0.8）mPa·s比（6.5-±0.8）mPa·s,（12.6±1.2）mPa·s比（22.6±5.2）mPa·s,（1.46±0.25） mPa·s比（1.89-±0.36） mPa·s;对照组：（5.5±0.9）mPa·s比（6.6±1.0）mPa·s,（16.3±7.2）mPa·s比（24.3-±6.2）mPa· s,（1.76±0.34）mPa·s比（1.93±0.57） mPa·s]（P＜0.05）,观察组治疗后血液黏度低于对照组,差异有统计学意义（P＜0.05）.结论 依折麦布对长期服用抗精神病药物导致的高血脂有调节作用,疗效显著且较为安全.

Regulation of blood lipids during receiving long-term antipsychotic treatment psychiatric patients by ezetimibe

Objective To investigate the regulation of blood lipids during receiving long-term antipsychotic treatment psychiatric patients by ezetimibe.Methods From April 2010 to August 2013,94 cases of mental illness associated with high cholesterol in fourth people＇s hospital of Urunqi were as a research object.According to the random number table method,the patients were randomly divided into two groups,each had 47 cases.The control group received simvastatin 20 mg/d,observation group accepted simvastatin 10 mg/d and ezetimibe 10 mg/d.After treatment for 8 weeks,blood rheology in two groups of patients were compared and analyzed.Results After treatment,except Apo-A,the lipid levels of two groups decreased to varying degrees（P ＜ 0.05）.The Total cholesterol,triglycerides,high-density lipoprotein cholesterol,low density lipoprotein cholesterol and apolipoprotein B in the observation group after treatment were all lower than those in the control group （5.0 ± 0.8） mmol/L vs （5.2±0.7）mmol/L,（1.6 ±0.8）mmol/L vs （1.9 ±0.8）mmol/L,（1.11 ±0.34）mmol/L vs （1.07 ± 0.49） mmol/L,（2.42 ±0.83）mmol/L vs 3.08 ± 0.67）mmol/L,（1.15 ±0.31）g/L vs （1.34 ± 0.49） g/L] （all P ＜ 0.05）.The blood viscosity of the observation group and control group were all lower than before treatment observation group：（4.2 ±0.8）mPa · s vs （6.5 ±0.8）mPa · s,（12.6 ± 1.2）mPa · s vs （22.6 ±5.2）mPa · s,（1.46 ± 0.25） mPa · s vs （1.89 ± 0.36） mPa · s ; control group：（5.5 ± 0.9） mPa · s vs （6.6 ± 1.0） mPa · s,（16.3±7.2）mPa·svs （24.3±6.2）mPa· s,（1.76±0.34）mPa· s vs （1.93 ±0.57）mPa· s] （allP＜ 0.05）,after treatment blood viscosity of the observation group was lower than the control group,the difference was statistically significant （P ＜ 0.05）.Conclusion Ezetimibe has a significant effect and security effect for the high cholesterol which caused by long-term use of antipsychotics.