左乙拉西坦对婴儿痉挛患儿免疫功能的影响研究

目的 观察左乙拉西坦对婴儿痉挛患儿免疫功能的调节作用.方法应用散射比浊法测定婴儿痉挛患儿左乙拉西坦治疗起始剂量10 mg/（kg·d）,2次/d,每周添加10 mg/（kg·d）至最小有效量,最大剂量40 mg/（kg·d）]前后外周血免疫球蛋白水平;应用流式细胞仪测定患儿治疗前后的T细胞亚群,并与25例正常婴儿比较.结果 病例组患儿治疗前血清IgG、IgA水平低于正常对照组（3.94±0.64）g/L比（5.19±0.53）g/L;（0.26±0.08）g/L比（0.33±0.12）g/L]（P＜0.05）,IgM高于正常对照组（0.91±0.25）g/L比（0.71±0.29）g/L]（P＜0.05）;治疗后IgG、IgA、IgM水平均无明显变化（均P〉0.05）.病例组治疗前较正常对照组CD4降低（38±7）%比（44±8）%]、CD8增高（23±6）%比（16±8）%],CD4/CD8（1.62±0.28）比（2.55±0.21）]明显降低（均P＜0.05）;治疗后CD8较治疗前下降治疗后为（18±5）%]（P〈0.05）,CD4/CD8较治疗前上升（1.98±0.25）]（P＜0.05）.结论 婴儿痉挛患儿存在免疫功能的紊乱,左乙拉西坦对其免疫功能具有一定的调节作用.

Effects of levetiracetam on immunological function in children with infantile spasms

Objective To explore the regulatory effect of levetiracetam on immuno logical function in children with infantile spasms. Methods Turbidimetric methods was using to detect the immunologbulins. Flow cytometry was applied to measure the proportion of lymphocytic subsets in peripheral blood in infants with West syndrome before and after levetiracetam treatment and 25 normal health infant. Results IgG, IgA levels were significantly lower than those in the control group（3.94±0.64）g/L vs （5.19±0.53）g/L;（0.26±0.08）g/L vs （0.33±0.12）g/L] （P〈0.05）, IgM were significantly increased （0.91±0.25）g/L vs （0.71±0.29）g/L] （P〈0.05）. CD4 （38±7）% vs （44±8）%] were decreased （P 〈0.05） and CD8 （23±6）% vs （16±8）%] were increased（P 〈0.05）, CD4/CD8 （1.62±0.28） vs （2.55±0.21）]were significantly lower （P〈0.05）. IgG, IgM and IgA levels were not different after levetiracetam treatment compared to before treatment. CD8 was decreased （18±5）% vs （23±6）%] and CD4/CD8 were increased （1.98±0.25） vs （1.62±0.28）]after levetiracetam treatment compared to before treatment. Conclusion Immunological function is abnormal in children with infantile spasms and levetiracetam can regulate childrens＆#39;s immunological function.